David1949 wrote:Well I had the CCSVI procedure 17 months ago. It didn't help with my worst problem, the gimpy leg. But I do dream now.
I think my muscles, which have been increasingly atrophic for nine years, are going to have a tough time coming back, at age 59. It took a lot of hiking and biking to get them where they were. The nerves still don't work. I don't dream. So consider yourself to have gotten some benefit, anyway.
Forget about velocity. It is indeed about blood flow.
This article on caffeine and brain blood flow is very complete.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748160/
I won’t say that it can have an impact on your disability. But i think it is something to consider in the CCSVI paradigm.
Coffee is used since no more than 300 years in Europe. Which is ridiculous on the evolution scale. In comparison we eat grains and dairies since 10000 years and we are still not made to eat that.
Flow velocity is probably more meaningful in arteries assumed to be non-stenotic (patent).
Unless a measurement includes vessel diameter changes and pressure changes, you can't really tell what is going on. I think the real action is in venules, which caffeine shrinks, withdrawal grows, and are responsible for headache. Caffeine probably affects both veins and arteries.
In order not to starve the brain of oxygen, when caffeine shrinks venules (and capillaries?), probably there is a corresponding pressure increase. The diameter change makes the velocity increase, as decreasing the nozzle size increases water velocity from a hose. The pressure changes will also make velocity increase, but in a straight-line fashion, whereas diameter change increases or lowers it by the fourth power of the diameter. So your heart cannot compensate for a drastic change in diameter of a major vessel, as might happen if you choked an artery.
If it were a very serious problem, people would not drink coffee. Maybe all the smooth muscle exercise growing and shrinking vessels keeps it more fit, with better tone. I don't know,
The way changing vessel size affects us at night, in CCSVI, may be that the total cross-sectional area for venous neck flow is not fully compensated for, by increased number of corollaries. So when jugulars are expected to be in service, when we are lying down, there is not enough flow. We are now thinking the oxygen carried by upright veins plus jugulars when we are prone, is no longer enough to support new oligodendrocyte growth or remyelination. The oligos are more present and we do more myelin repair in REM sleep.
Most people don't drink coffee when they want to sleep. First thing in the morning is probably ok, though. You won't lose much REM sleep that way.