Italian team studies Chiropractic care for MS CCSVI

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Italian team studies Chiropractic care for MS CCSVI

Postby vesta » Sat May 14, 2016 8:42 am

Hello Dr. Flanagan:

Hugo Macia (his blog - http://www.secretosdelaesclerosismultip ...
has just sent me this PubMed study which implies that Neurologists are finally considering the "mechanical" aspect of CCSVI. The Italians are apparently the most interested because one of their own (Dr. Zamboni) proposed the CCSVI theory for MS. How would you undertake, improve on, such a study?


Preliminary results after upper cervical chiropractic care in patients with chronic cerebro-spinal venous insufficiency and multiple sclerosis.
Mandolesi S, et al. Ann Ital Chir. 2015 May-Jun.

PURPOSE: The aim of the study is to evaluate the clinical and X-ray results of the Upper Cervical Chiropractic care through the specific adjustments (corrections) of C1-C2 on patients with chronic venous cerebral-spinal insufficiency (CCSVI) and multiple sclerosis (MS).

METHOD: We studied a sample of 77 patients before and after the Upper Cervical Chiropractic care, and we analyzed: A) The change of the X-ray parameters; B) The clinical results using a new set of questions. The protocol of the C1- C2 upper Cervical Chiropractic treatment, specific for these patients, lasts four months. From a haemodynamic point of view we divided the patients in 3 types: Type 1 - purely vascular with intravenous alterations; Type 2 - "mechanical" with of external venous compressions; Type 3 - mixed.

RESULTS: We found an improvement in all kinds of subluxations after the treatment with respect to the pre-treatment X-ray evaluation, with a significant statistical difference. The differences between the clinical symptoms before and after the specific treatment of C1-C2 are statistically significant with p<0.001 according to the CHI-Square test revised by Yates.

CONCLUSIONS: The preliminary X-ray and clinical improvements of the Upper Cervical Chiropractic corrections on C1- C2 on these patients with CCSVI and MS encourage us to continue with our studies. We believe that the Upper Cervical correction on C1-C2 could be the main non-invasive treatment of the CCSVI mechanical type in patients with MS. Further studies are required to evaluate the correlation between the Upper Cervical Chiropractic correction on C1-C2 on the cerebral venous drainage and the cerebro-spinal fluid.

KEY WORDS: CCSVI, Multiple sclerosis, Upper Cervical Chiropractic care.

26228993 [PubMed - in process]

Best regards, Vesta
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Re: Italian team studies Chiropractic care for MS CCSVI

Postby Robnl » Tue May 17, 2016 12:19 am

Interesting, Vesta!
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Re: Italian team studies Chiropractic care for MS CCSVI

Postby CureOrBust » Tue May 17, 2016 12:26 am

vesta wrote:How would you undertake, improve on, such a study?
The usual way. Double blind, placebo controlled and less conflicting interests.
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Re: Italian team studies Chiropractic care for MS CCSVI

Postby vesta » Tue May 17, 2016 8:31 am

There are a series of studies by Italian Vascular specialists beginning to look at mechanical aspects of CCSVI MS. Here is another published on Pub Med. The researchers readily admit this is a new topic of research in need of more study. Type in the name of a researcher to see studies being done. For those like Dr. Flanagan who has insisted for over 30 years that body structure pathologies can lead to MS (among other things) we are finally getting somewhere with the Medical community. Regards, Vesta


Ann Ital Chir. 2015 Jul-Aug;86(4):293-300.

C1-C2 X-Ray assessment of misalignment parameters in patients with Chronic Cerebra-spinal Venous Insufficiency and Multiple Sclerosis versus patients with other pathologies. Mandolesi S, Marceca G, d'Alessandro A, Desogus A, Ciccone MM, Zito A, Manconi E, Niglio T, Mandolesi D, d'Alessandro A, Fedele F.

PURPOSE: The complete compression of the internal jugular veins, in front position, shows a prevalence of 48% and it is equally distributed in the various segments of these veins in patients with Chronic Cerebro-Spinal Venous Insufficiency (CCSVI) and Multiple Sclerosis (MS). The aim of this search is to identify radiological dislocation of C1-C2 as specific markers in patients with CCSVI and Multiple Sclerosis (MS).

METHOD: We investigated 386 patients suffering from CCSVI and Multiple Sclerosis and a control group of 156 patients without MS.

RESULTS: The assessment of Anterior Intrusion shows the following average values: in the group with CCSVI and MS: 4.29 ±1.48 mm while in the control group: 3.78 ±1.45 mm (p = 0.0008).The evaluation of the Right Laterality shows the following average values: in group with CCSVI and MS: 2.31±1.41 mm, in control group: 1.97 ±1.28 mm (p = 0.0426). We found also that a longer duration of the disease corresponds to a higher severity of the pathological condition (p <0.0001).

CONCLUSION: Data analysis of C1-C2 X-Ray parameters shows statistical significance of severe anterior intrusion and right laterality misalignment in the people with CCSVI and MS, that are two to three times more frequent as compared to controls. Considering the novelty of this work and the total absence of scientific similar works able to confirm this data, it is necessary to continue these studies in order to improve the clinical management of these patients and to perform therapeutic strategies based on venous decompressive treatments both surgical that manipulatives.

KEY WORDS: CCSVI, Multiple Sclerosis, Venous Compressive syndrome, X-Ray C1-C2.

PMID: 26344031 [PubMed - in process]
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