brain drain

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

brain drain

Postby 1eye » Sun Oct 08, 2017 2:16 pm

https://www.nih.gov/news-events/news-re ... our-brains

The question in my mind is: is it nocturnal (i.e. during REM sleep). If it is, (the mice drained during diurnal sleep -- i.e., during the day) we may have a way to deal with Alzheimers -- by getting good sleep!

In fact, it should be a goal of the makers of sleeping medication to trigger the brain's "rinse cycle". Are you listening, drug manufacturers?
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Re: brain drain

Postby NHE » Mon Oct 09, 2017 12:01 am

1eye wrote:https://www.nih.gov/news-events/news-releases/nih-researchers-uncover-drain-pipes-our-brains

The question in my mind is: is it nocturnal (i.e. during REM sleep). If it is, (the mice drained during diurnal sleep -- i.e., during the day) we may have a way to deal with Alzheimers -- by getting good sleep!

In fact, it should be a goal of the makers of sleeping medication to trigger the brain's "rinse cycle". Are you listening, drug manufacturers?

Just be wary of anticholinergic sleep aid medications.

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A natural brain drain ??

Postby MarkW » Mon Oct 09, 2017 1:09 pm

:?: Could this be linked to CCSVI??

Abstract
Here, we report the existence of meningeal lymphatic vessels in human and nonhuman primates (common marmoset monkeys) and the feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI. On T2-FLAIR and T1-weighted black-blood imaging, lymphatic vessels enhance with gadobutrol, a gadolinium-based contrast agent with high propensity to extravasate across a permeable capillary endothelial barrier, but not with gadofosveset, a blood-pool contrast agent. The topography of these vessels, running alongside dural venous sinuses, recapitulates the meningeal lymphatic system of rodents. In primates, meningeal lymphatics display a typical panel of lymphatic endothelial markers by immunohistochemistry. This discovery holds promise for better understanding the normal physiology of lymphatic drainage from the central nervous system and potential aberrations in neurological diseases.
https://doi.org/10.7554/eLife.29738.001
Mark Walker - Oxfordshire, England. Retired Pharmacist. 16 years of study about MS.
CCSVI Comments:
http://www.telegraph.co.uk/news/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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Re: brain drain

Postby cheerleader » Sun Oct 15, 2017 12:39 pm

MarkW wrote::?: Could this be linked to CCSVI??


Hi Mark--

Having spoken with both Jonathan Kipnis and Maiken Nedergaard about this---their answer is yes. As the jugular veins are the drainage outlet for these newly discovered lymphatic vessels, any type of slowing, blockage, stenosis, valvular issues or hampering of outflow may well be related to neurodegenerative disease, including MS. More research ahead. And NHE and 1eye are right...as the jugular veins are used when we sleep, when our brain is cleansed of toxins, proteins and metabolites, working jugular veins are essential. I write about all of this research and the discussions I've had with these researchers on my blog.

on the Kipnis Lab discovery of meningeal lymphatic vessels
http://ccsviinms.blogspot.com/2015/06/a-stunning-discovery.html

on my visit to the Nedergaard Lab (her group discovered the brain's cleansing mechanism, which happens when we sleep.) http://ccsviinms.blogspot.com/2015/04/g ... gaard.html

on the myth of the "immune priveleged brain" and EAE
http://ccsviinms.blogspot.com/2015/06/r ... books.html

Jugular stenting in 2009 and cardiovascular health pursuits may well be why my husband had a reversal of gray matter atrophy, no new lesions, and is still jogging and working full time 10 years after MS diagnosis.

thought the NIH corroboration of this research might deserve a pop in. Glad I did. Hope all are well.

Joan
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Re: brain drain

Postby 1eye » Thu Oct 19, 2017 7:28 am

OK look, this is important. Someone needs to contact the Alzheimer's Society and we need to find out tout suite (right now) whether the procedure (maybe even including stenting) is a treatment for Alzheimers. Millions of brains are at stake. Please, let's get it tried, for heaven's sake. Can Dr. Sclafani please help?
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Re: brain drain

Postby violin » Wed Oct 25, 2017 9:55 pm

Right, Dr. Sclafani has written that the venoplasty treatment of CCSVI should be evaluated and considered for neurologic disease in addition to MS.

If anyone learns more about brain drain, CCSVI, and Alzheimers, please post. I need to know.
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