I like the DVA one, interesting material. It makes you wonder if the congestion makes them show up more. but I hesitate to add it to our research thread--I know from experience with the CPn Help research pages that if you include everything they get too cumbersome and people give up.
Did we cover how the blood back up leads to myelin damage? How does repair of the damage bring resolution to the issue of poorly conductive axons? Ken
the altered hemodynamics causes the loss of shear stress which means that the normal flow of blood makes the BBB and the endothelium--the "skin" of the blood vessels-- strong but when there are eddies and chaotic currents the altered flow causes the endothelium to break down (this is shown in animal models) and this means he vessel becomes leaky and fluids from the blood, inflammatory cells etc, goes through into the tissue. In an ankle with a blockage above it this makes a puffy swollen ankle and it may eventually become a venous stasis ulcer where the tissue changes in many predictable ways
Repairing the blocked vein results in healing see this here: watch it all so you see the open ulcer back of the leg.......
Ya think that'd bother a brain if it was going on there instead of the ankle?
please read the schelling book, pages 28-31 speifically for the myelin and how it is the damaged party in this model. The book has a nice table of contents on the left side and you can go to the subject that interests you. He covers the research known at that time--roughly '83--and how this new venous idea accounts for the same material. Essentially the myelin is fragile and the pressure is hard on it and the oligodendrocytes.
As for healing if you relieve the blockage the blood flow is returned to normal and the leaking through the endothelium BBB is stopped. The area can heal normally without that problem going on. If you watched that whole you tube video the doctor is showing a healed venous ulcer on the front of the leg that has closed up after surgery to relieve the blockage, and at the end of the video he turns the ankle around and shows you one that is still open but healing.
You can see how scarred, hard and damaged even the "healed" area is.
Multiple sclerosis means many scars, but it got that name because when they autopsied the brains of MS patients they found these hard areas that thye could see and feel. Nt the hard scarred tissue in the ankle.
Venous pathology causes issues that are very similar to MS lesions and the Zamboni 'o6 paper "The Big IDea..." has a table that shows the similarities. I won't paste it in again, but you can see it that paper.