the iron angle

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

the iron angle

Postby zap » Mon Jun 15, 2009 9:23 pm


I know everyone is really focused on the downstream stenoses, but Zamboni's paper also focuses on the immediate mechanism of damage - namely, he thinks high iron concentrations are a cause, and not just a symptom of the lesions and damage.

At the end of his paper Zamboni suggests investigation into "induced iron deficiency" - perhaps indicating we might try avoiding foods high in iron?
Or go for iron-binding proteins, iron inhibitors, chelators, therapeutic phlebotomy (blood donation) ... mimic the paths taken by those with too much iron (hemochromatosis / hemosiderosis)?

So has anyone had their blood iron levels checked? Hemosiderin in the urine maybe?

Does Dake also take interest in the iron angle?
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DMT1: potential iron toxicity treatment tangent

Postby zap » Mon Jun 15, 2009 10:23 pm

This was an interesting tangent ...

The paper noted that since the presence of iron increases “DMT1 messenger-RNA and function, we suspect that the lung may have evolved a specific response to iron in order to protect the epithelial surface from oxidative stress….Management of iron in particles is also critical to minimize the metal ions’ availability to microbial invaders that may arrive with the same particles,” it added ... Ghio said the mechanisms uncovered in their experiments so far indicate that “if we follow the iron, we may be able to change the types of toxic reactions to all kinds of particulates and fibers and the metals they carry.” ... research already is underway to see what functions DMT1 might be playing in the other organs where it is found, including the liver, kidney and brain." ... id=2542486

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Postby wobbly » Tue Jun 16, 2009 10:31 am

there is def something with the iron deal heard it alot in italy/ but remember no `1 no s me/ PEACE :?: :?:
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Postby Terry » Tue Jun 16, 2009 5:26 pm

My iron stays low, Zap, and I let it stay low. Also, my RDW is kind of high (at least it was in 2007), a consequence probably of low iron. I think a high RDW means that the red blood cells vary in size a bit too much. I have not supplemented the low iron to increase (I am not amenic) because there has been some written about too much iron in MSers brain and also b/c "iron is oxidative" (a quote from a past doc).
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Postby mrhodes40 » Wed Jun 17, 2009 8:34 am

Iron is very irritating to the tissue if blood extravasates into the tissue. It induces inflammation and an oxidative response.

It is part of the overall syndrome of changes that take place when CCSVI happens, and one reason why this disease is inflammatory, even though probably not autoimmune.
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