CCSVI and new research on "myelin stall out"

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

CCSVI and new research on "myelin stall out"

Postby cheerleader » Sun Jul 05, 2009 11:23 am

ScienceDaily (July 1, 2009) — Scientists have uncovered new evidence suggesting that damage to nerve cells in people with multiple sclerosis accumulates because the body's natural mechanism for repair of the nerve coating called "myelin" stalls out.

The study, published July 1, 2009, in the print edition of Genes & Development, was conducted by scientists at the University of California, San Francisco and University of Cambridge. The research was led by co-senior investigator David Rowitch, MD, PhD, a Howard Hughes Medical Institute investigator at UCSF.
The investigation, conducted in mice and in human tissue, showed that repair of nerve fibers is hampered by biochemical signals that inhibit the development of cells known as oligodendrocytes, which function as repair workers in the brain.
Oligodendrocytes form a protective sheath, known as myelin, that insulates the fibrous cables, or axons, radiating from nerve cells. In multiple sclerosis, the immune system's T cells and B cells attack oligodendrocytes, ultimately damaging the myelin sheath to the point that the electrical signals transmitted by the axons beneath it are disrupted. ... 102908.htm

How would this research further confirm the mechanics of CCSVI? With chronic (ongoing) venous insufficiency, the body continues to send in the "clean up crew" to get rid of the damaged tissue. But once MS becomes progressive- when the stenosis closes down the vein completely- the damaged tissue occurs chronically...the clean-up crew never gets the message to leave. And myelin cannot regrow where the macrophages stay. This is why immune ablating medicines work - incompletely. The macrophages are stopped from doing their job long enough so that some myelin can regrow....BUT the cause of macrophage instigation is not halted. CCSVI continues....

ScienceDaily (Mar. 4, 2007) — Macrophages are the immune cells that engulf and destroy the debris of damaged tissue to enable the healing process to begin. Their presence at the scene of damage is critical, but once their task is complete, it is just as critical that macrophages exit rapidly, ending the inflammatory process and making way for regrowth. In fact, the continued presence of macrophages could damage tissue, compromising repair.

While researchers know a great deal about the molecular machinery that launches this cellular cleanup crew into action, little has been known about the just-as-critical exit process.

If chronic assault on the brain and spine is stopped- by allowing healthy venous flow- the macrophages should pack their bags. No more hypoxia and cell death- no more need for a cleanup crew. The oligos can come back home and remyelinate.

Oh, I can't wait to see Jeff's new MRI tomorrow....
Last edited by cheerleader on Sun Jul 05, 2009 2:26 pm, edited 1 time in total.
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
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Postby mrhodes40 » Sun Jul 05, 2009 11:33 am

Great speculation! I like the tie in to CCSVi and it makes perfect sense.

Tomorrow will be great Cheer I can't WAIT to hear what they say. It is gonna be good news I just know it.
I'm not offering medical advice, I am just a patient too! Talk to your doctor about what is best for you... This is my regimen thread Read my book published by McFarland Health topics
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Postby chrishasms » Sun Jul 05, 2009 11:48 am

Last edited by chrishasms on Sun Dec 06, 2009 12:27 pm, edited 1 time in total.
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Postby Loobie » Sun Jul 05, 2009 12:18 pm

Man, that's the thing I always go back to; how can it repair? Good stuff Cheer.
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Postby javaneen » Sun Jul 05, 2009 1:03 pm

Great info Cheer! I can't wait to hear about the MRI tomorrow either! What an exciting week we have coming up. Good luck!
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Postby peekaboo » Sun Jul 05, 2009 1:51 pm

As an ex Chicago Cubs fan (still luvem) I'm out on the bleachers drinkin the beers and shouting for you guys.... :) :) :)
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