OK...the collagen discussion was from my notes in Bologna.
Dr. Gabbiani took 5 specimens from IJV tissue removed by Dr. Zamboni from some of the patients he treated endovascularly. The tissue was from the area NOT damaged by angioplasty.
He compared it to healthy tissue from autopsy controls.
He looked at eosin, hematoxylin, Miller’s elastic stain and masons truchrome.
He found smooth muscle cells were numerous and increased in MS compared to controls. He then used isoelectric focusing to measure contractions in the smooth muscle cells via actin heterogeneity to ID the smooth muscle cells in the veins.
There is an increased expression of smooth muscle actin in MS, much more than controls.
By red staining for collagen and using unpolarized and polarized light, he saw that there is less collagen 1 type fibers in the MS jugular vein tissue, and more collagen III fibers in MS. This is the exact opposite of the controls.
Connective tissue in MS switches from collagen I to collagen III and this takes place in the IJVs. THis switch also happens in fibromatosis, colloids and hypertrophied scars, and this remodeling may play a role in CCSVI disturbances.
He did not posit which came first, collagen changes or reflux. We are still in the early stages, and even though we all may love to play guess which came first, it's up to the docs to do the research.
As far as have a coke and a smile...it's just not going to be that easy. Read all the research, take notes, find the best way YOU know how to present the info to doctors. Print out Ashton Embry's article, the Zamboni research, the Haacke website. There is a plethora of info out there now -all housed on this site or the Facebook page. Go! Rah! You can do it people!
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS