I read about some unexpected contra-indications to aspirin a short while ago, and remember being shocked. I'm sorry that I don't remember the details, or have links. I thought it was quite serious though.
I use very high doses of nattokinase (enzymes), and there is ample clinical evidence that it reduces blood pressure, and does all good things for heart and vasculature. Try PubMed for more info. Or Google (just the Med sites - not Johnson's anonymous health tips .com)
I would recommend avoiding any formulations that have serraptase in them - that breaks down fibrin (so does natto, but not as aggressively), and the plaques are fibrin (scar tissue). I have been having a long exacerbation since I started the serraptase, and I have a theory that the plaques are breaking down in my brain, and allowing more iron in, and the immune system too.
Talk to your doctor about the nattokinase. Any decent cardiologist will know about it.
Rutin is very good too - found in orange root vegetables like yams, rutabaga, etc. You can buy it in supplement form.
Inclined Bed Therapy looks very promising too. There is a link on the main page.
Best of luck, and remember that I am only relating my own thoughts, and not medical advice.
My name is not really Johnson. MSed up since 1993