My question is whether having a low body weight increases adverse side effects with Copaxone, and maybe the other RABs.
Back in January 2005, I finally got my Copaxone and gave it a try - unfortunately I lasted only five days with it. Injecting it made my blood pressure drop, so I would have to inject and then lay down for at least a half hour, sometimes longer, or I would faint. The injections into my stomach or hip areas weren't so bad, I would get a reaction that was like a bee sting, with a red area about half the size of my palm. The injections to my limbs were awful. The reaction on one thigh was a big, bubbling lump the size of my hand, with redness from my knee to hip. About two days after that shot, I had a weird muscle reaction under where the shot went in, the muscle bucked and twisted like a snake for several hours, the motion easily seen through the leg of my jeans. Then that reaction went away and did not return. My last shot was to the back of one arm, and I got a big wheal that ran from my shoulder to my elbow.
When I called Shared Solutions to make note of my problems, the nurse asked my body weight, which at that time was about 115-120 pounds. (I'm now five pounds lighter than that). She remarked that maybe I was "too small". Given the lipoatrophy risk, she said there was no way for me to just rotate the injections between stomach and hip. I decided then that Copaxone was not going to work for me.
That got me thinking - the Copaxone dose everyone is supposed to inject is the same, regardless of how much they weigh or how much body fat they have. I read an magazine interview with Clay Walker, a country-western singer with MS. He apparently has taken Copaxone for several years, so he must have a good tolerance for it, and the article stated he had gone on a healthy diet and lost weight from 200 down to a lean 170 pounds. That is at least 50 pounds more than my weight. Yet the drug amount prescribed is the same!
I've read some other posts for the "RABs" that indicated lower body weight/low BMI people have had some problems with those drugs as well. I wonder how many other injectable drugs for other conditions are "one size fits all". Insulin dose, probably the most commonly chronically injected drug worldwide, is of course tailored to each patient.
Has anyone else run into this issue of body weight or BMI with Copaxone?