Copaxone--Mechanism of Neuroprotection

A board to discuss the Multiple Sclerosis modifying drug Copaxone

Copaxone--Mechanism of Neuroprotection

Postby Shayk » Fri Jun 06, 2008 5:46 pm

Hi again

This is old news but I thought I'd post it anyway.

T cell independent mechanism for copolymer-1-induced neuroprotection
Despite active investigation of copolymer-1 (Cop-1) for nearly 40 years the mechanisms underlying its neuroprotective properties remain contentious. Nonetheless, current dogma for Cop-1 neuroprotective activities in autoimmune and neurodegenerative diseases include bystander suppression of autoimmune T cells and attenuation of microglial responses. In this report, we demonstrate that Cop-1 interacts directly with primary human neurons and decreases neuronal cell death induced by staurosporine or oxidative stress.

Dendritic cells (DC) uptake Cop-1, deliver it to the injury site, and release it in an active form.

Still doesn't make it any better than placebo, but it looks like whatever it "does" may or may not be dependent on impacting "autoimmune T cells" :wink:

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