This trial only used 2 g of omega 3 daily. It did NOT make any effort to reduce omega 6 levels. Chris Kresser has a series of articles on omega 3 omega 6 ratio that will help you understand better why this trial was doomed to failure
If we think about being poor and in debt as an analogy for our omega 3 omega 6 economy.
The anti inflammatory omega 3 represents income and the pro inflammatory omega 6 represents expenditure and debt.
If you already have too much debt and current expenditure a little more money Say £2 a day, will make very little difference because the bank/taxman/debtors will have first dabs on it. ONLY after you have cleared your debts and your current income matches current expenditure will £2 a day extra build to provide significant savings benefit.
Most UK adults will have omega 6 about 20 ~30 times higher than their omega 3 levels so until the omega 6 is reduced no amount of omega 3 will be effective. Dr Davis of the heartscanblog uses 6000 mg per day of omega-3 fatty acids, EPA and DHA, (that's 3 times the trial amount) will drop Lp(a) after one year. Some have required two years.
and Dr Davis is telling his patients to IMPROVE Vitamin D status with 10,000iu/daily, use EFFECTIVE amounts of magnesium and also use melatonin.
If you want to get out of debt you need to use all possible means to increase your income and all possible routes to cut your expenditure. Your plan has to cover every option.
With your omega 6 debt/expenditure you have to find every way possible to eliminate all sources of omega 6 at the same time as using all possible routes to increase your anti inflammatory reserves. It isn't a matter of doing one or the other. You have to do EVERYTHING possible on both sides of the equation and you have to do it ALL at the same time.
Vitamin D is ongoing battle to keep 25(OH)D ABOVE 125nmol/l 50ng/ml the level at which vitamin D is most powerfully anti inflammatory. That will require at least 1000iu for every 25lbs you weigh and maybe as much as 10,000iu/daily and it will take at least a year to attain and maintain a reasonable level. Cityassays vitamin D blood spot test for £25
Magnesium requires in the region of 5 to 10 milligrams per day per kilo of ideal body weight or 2.5 to 4.5 milligrams per day per pound of ideal body weight. So someone 70kg requires at least 350mg/d and ideally a total from all sources of 700 mg. daily. So s 100mg supplement with each meal and another before bedtime will provide 400mg from supplements and the extra from food/water sources will make up the difference.
Melatonin is important not only for sleep. 400x more melatonin is produced in your digestive tract as it regulates metabolism and people who are short of melatonin (shift workers) tend to be more overweight.
Dr Davis suggests Time Release forms. The dose varies with age, with 1 mg effective in people younger than 40 years, higher doses of 3, 5, even 10 or 12 mg in older people. Sustained-release preparations also should be taken in slightly higher doses.
It isn't that on it's own omega 3 can solve your MS problems, it won't BUT reducing your inflammatory status will improve your immune function and enable your body to better fight inflammation and in doing so will reduce your pain levels and risk of further flares. But in the same way you will only get out of debt if you have a plan that takes account of maximising income streams and minimising all forms of debts and expenditures so to will it be impossible to solve your inflammation crisis by just paying attention to one small aspect of the situation by using only one form of anti inflammatory agent and too little and for too little time.
We have wasted far too much time messing around with ineffective forms and amounts it really is about time Researchers used a little common sense.