So why not MS???

A board to discuss various diet-centered approaches to treating or controlling Multiple Sclerosis, e.g., the Swank Diet

So why not MS???

Postby JFH » Mon Jan 10, 2005 9:39 am

The BBC are reporting today a study that shows diet has a significant effect on the risk of contracting breast cancer.

Olive oil acid 'cuts cancer risk'

The Mediterranean diet is believed to be very healthy
Scientists in Chicago say they have uncovered why a Mediterranean diet rich in olive oil seems to cut the risk of developing breast cancer.
The key is an ingredient of olive oil called oleic acid, they say.

Northwestern University laboratory tests on breast cancer cells showed the acid sharply cut levels of a gene thought to trigger the disease.

Cancer charities said the study, in Annals of Oncology, was interesting, but more research was needed.

Much more work will be needed to determine whether this is of any importance for breast cancer in women

Professor Tim Key
The researchers found that oleic acid cut activity levels of a gene called Her-2/neu, which occurs at high levels in over a fifth of breast cancer patients and is associated with highly aggressive tumours with a poor prognosis.

Not only did oleic acid suppress activity of the gene, it also boosted the effectiveness of a breast cancer drug called herceptin, which has helped to prolong the lives of many patients.

Lead researcher Dr Javier Menendez said: "Our findings underpin epidemiological studies that show that the Mediterranean diet has significant protective effects against cancer, heart disease and ageing."

It's ringed of course by the usual "more research is needed" but a this thought occured to me: If a diet change positively effects progression of one disease in some people why shouldn't a suitable change postively effect mine :)
More research is needed indeed!! 8)
http://news.bbc.co.uk/2/hi/health/4154269.stm
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Postby OddDuck » Mon Jan 10, 2005 4:08 pm

John,

Did you see my mention in the regimens section regarding oleic acid? It IS also supposed to help MS. :wink:

I think I also mentioned oleic acid real quick in some of my research a long time ago.

I get mine (oleic acid - i.e. Omega 9) along with the fish oil combination supplement that I take. It is supposed to assist with axonal growth (or should I say "so I heard").

Deb

EDIT: I'll just post one abstract regarding the above:

Brain Res. 2003 Oct 24;988(1-2):1-8. Related Articles, Links


Oleic acid induces GAP-43 expression through a protein kinase C-mediated mechanism that is independent of NGF but synergistic with NT-3 and NT-4/5.

Granda B, Tabernero A, Tello V, Medina JM.

Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca, Edificio Departamental, Plaza de los Doctores de la Reina s/n, 37007 Salamanca, Spain.

We have recently shown that the presence of albumin in astrocytes triggers the synthesis and release of oleic acid, which behaves as a neurotrophic factor for neurons. Thus, oleic acid promotes axonal growth, neuronal clustering, and the expression of the axonal growth-associated protein, GAP-43. In this work we show that oleic acid upregulates GAP-43 expression by a protein kinase C (PKC)-dependent mechanism. Since GAP-43 expression has been shown to be upregulated by several neurotrophins, we investigated the relationship between the effect of oleic acid and that of NGF, neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5) on GAP-43 expression. Our results indicate that NGF is not involved in the neurotrophic effect of oleic acid because the addition of NGF did not modify the effect of oleic acid on GAP-43 expression. Neither NT-3 nor NT-4/5 alone modified GAP-43 expression. However, NT-3 and NT-4/5 acted synergistically with oleic acid to increase GAP-43 expression. The lack of effect of NGF as compared to other neurotrophins is not unexpected since we have not found TrkA expression under our experimental conditions. The effect of oleic acid on GAP-43 expression must be independent of autocrine factors synthesized by neurons because this effect was also observed at low cellular densities. In conclusion, our results indicate that oleic acid behaves as a neurotrophic factor, inducing GAP-43 expression through a PKC-mediated mechanism that is not mediated by other neurotrophic factors but that is strongly synergized by NT-3 and NT-4/5.

PMID: 14519521 [PubMed - indexed for MEDLINE]
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