Glucosamine

A board to discuss future MS therapies in early stage (Phase I or II) trials.

Glucosamine

Postby bromley » Tue Nov 29, 2005 3:02 am

Dignan has already highlighted the research about this supplement. Here is another summary of the research:

http://www.medicalnewstoday.com/medical ... wsid=34218


By coincidence I found a jar in my bathroom cabinet so I have started taking them. Has anyone who has taken them noticed any improvements?


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Postby gkalman » Thu Dec 01, 2005 1:43 pm

There was definitely an observable reduction in my wife's joint pain and the frequency of headaches when she started taking a glucosamine+chondroitin supplement about two months ago. (I am attributing those rightly or wrongly to MS.)

Just a single data-point, but seems to be helping right now.
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Postby Melody » Fri Dec 02, 2005 6:03 am

We checked it out and have decided to try 1500mg of liquid Glucosamine Sulfate but has anyone gone with the combination below?????? John just started on Nov 30 but the liquid brags you will feel results in 7-14 days. Have no idea if that's true and unlikely to as John isn't feeling bad right now :lol: :lol:

Glucosamine Sulfate - Chondroitin Sulfate
January 30, 2004



These two compounds have gained widespread use for the treatment of arthritic conditions. Though initially skeptical of "homeopathic" natural remedies, our patients have swayed our thinking by reporting excellent symptomatic relief, comparable to any non-steroidal (NSAID) drug. Additionally solid basic science studies and prospective blinded human studies have shown that glucosamine is effective in:

Reducing joint pain
Increasing lubrication of the joint
Stimulating cartilage matrix repair
Inhibiting enzymes that breakdown cartilage
Preserving joint space
Anti-inflammatory actions
The dosage that appears to be effective is 1500 mg of Glucosamine. The literature suggests that liquid forms are better absorbed than pills. The liquid (Joint Juice) or the pills can be taken once a day.

We have found no extra benefit from taking chondroitin sulfate although there may be some risk in that unlike glucosamine (from shellfish chitin) chondroitin is from the trachea of cows.

There is no allergic reaction known to glucosamine. No fish or shellfish products are present in the preparations.

There is no significant difference between the HCl and sulfate versions of glucosamine.

There is no over dosage of glucosamine possible that we are aware of.


Also See:
Glucosamine Index
Glucosamine Update
The Use of Glucosamine Sulfate in the Treatment of Osteoarthritis
Glucosamine References
Glucosamine Links

Other Links:
Glucosamine for Arthritis. The Medical Letter 1997.

Questions & Answers: NIH Study on Glucosamine/Chondroitin Sulfate for Knee Osteoarthritis. National Instititutes of Health September 15, 1999.
*Note: It is anticipated that a total of 1,124 patients will be recruited for the study. Patient recruitment is expected to begin in February 2000.

References:

McCarty F. The neglect of glucosamine as a treatment for osteoarthritis. Med Hypotheses 1994;42(5):323-27.

Vidal y Plana RR, Karzel K. Glucosamine: Its importance for the metabolism of articular cartilage. Fortschr Med 1980;98(21):801-6.

McCarty F. The neglect of gluscosamine as a treatment for osteoarthritis. Med Hypotheses 1994;42(5):323-27.

Lopez Vaz A. Double blind clinical evaluation of the relative efficacy of ibupro fen and glucosamine sulfate in the management of osteoarthrosis of the knee in out-patients. Curr Med Res Opin 1982;8(3):145-49.

Noack W, et al. Glucosamnine sulfate in osteoarthritis of the knee. Osteoarthritis Cartilage 1994;2:51-59.

Reichelt A, et al. Efficacy and safety of intramuscular glucosamine sulfate in osteoarthritis of the knee. Arzneimittelforschung 1994;44(1):75-80 [In German].

D'Ambrosio E, et al. Glucosarnine sulphate: A controlled clinical investigation in arthrosis. Pharmatherapeutica 1981;2(8):504-8 [In Italian].

Vajaradul Y. Double-blind clinical evaluation of intra-articular glucosamine in outpatients with gonarthritis. Clin Ther 1981;3(5):336-43.

Puljate JM, et al. Double blind clinical evaluation of oral glucosamine sulfate in the basic treatement of osteoarthrosis. Curr Med Opin 1980;7(2):110-14.

Rovati LC, et al. A large, randomized, placebo-controlled, double-blind study of glucosamnine sulfate vs. piroxicam and vs. their association, on the kinetics of the symptomatic effect in knee osteoarthritis. Osteoarthritis Cartilage 1994;2(supplement 1):56.

Crolle G, D'Este E. Glucosamine sulphate for the management of arthrosis: A controlled clinical investigation. Curr Med Res Opin 1980;7(2):104-9.

Muller-Fassbender H, et al. Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee. Osteoarthritis Cartilage 1994;2(1):61-69.

Dovanti A, Bignamini AA, Rovati AL. Therapeutic activity of oral glucosamine sulphate in osteoathrosis: A placebo-controlled double blind investigation. Clin Ther 1980;3(4):266-72.

Caps JC, et al. Hexosamine metabolism. I. The absorption and metabolism in vivo of orally administered D-glucosamine and N-acetyl-glucosamine in the rat. Biochem Biophys Acta 1966;127:194-204.

Kohn P, et al. Metabolism of D-glucosamine and N-acetyl-glucosamine in intact rat. J Biol Chem 1962;237(2):304-8.

Tesoriere G, et al. Intestinal abosorption of glucosamine and N-acetyl-glucosamine. Experientia 1972;28:770-771.

Qiu G., Gao S., Setnikar I. Efficacy and Safety of Glucosamine Sulfate vs. Ibuprofen in Patients with Knee Osteoarthritis. Osteoarthritis and Cartilage 5:60, 1997

Ronca G. Antiinflammatory Activity of Chondrontin Sulfate. Osteoarthritis and Cartilage 5:69, 1997

Bourgeois P., Chales G., Dehais J., Delcambre B., Dreyfus P., Kuntz, J., Rosenberg S. Efficacy and Tolerability of Chondroitin Sulfate 1200 MG/DIE vs. Chondroitin Sulfate 3x400 MG/DIE vs. Placebo. Osteoarthritis and Cartilage 5:69, 1997

Bucsi L., Poor G. Efficacy and Tolerability of 2x400 MG Oral Chondroitin Sulfate as a Single Dose in the Treatment of Knee Osteoarthritis. Osteoarthritis and Cartilage 5:69, 1997

Jimenez S., Dodge G. The Effects of Glucosamine Sulfate (GSO4) on Human Chondrocyte Gene Expression. Osteoarthritis and Cartilage 5:72, 1997

Rovati LC. The Clinical Profile of Glucosamine Sulfate as a Selective Symptom Modifying Drug in Osteoarthritis: Current Data and Perspective. Osteoarthritis and Cartilage 5:72, 1997

Reichelt A., Forster K., Fischer M., Rovati L., Setniker I. Efficacy and Safety of Intramuscular Glucosamine Sulfate in Osteoarthritis of the Knee. Arzneimittel-Forschung 44 (1) 75-80, 1994

Setnikar I., Giaccheti C., Zanolo G. Pharmacokinetics of Glucosamine in the Dog and Man. Arzneimittel-Forschung 36 (4) 729-735, 1986

Muller-Fassbender H., Bach G., Haase W., Rovati L., Setnikar I. Glucosamine Sulfate Compared to Ibuprofen in Osteoarthritis of the Knee. Osteoarthritis Cartilage (United Kingdom) 2/1 (61-69), 1994

Noack W., Fischer M., Forster K., Rovati L., Setnikar I. Glucosamine Sulfate in Osteoarthritis of the Knee. Osteoarthritis Cartilage (United Kingdom) 2/1 (51-59), 1994

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John was diagnosed Jan 2005. On lipitor 20mg .On Copaxone since July 4,2005. Vitamin D3 2000iu-4000iu (depending on sunshine months)June 10 2005(RX::Dr. O'Connor) Omega 3 as well Turmeric since April 2005. Q10 60mg. 1500mg liquid Glucosamine Nov 2005.
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Postby viper498 » Fri Dec 02, 2005 1:39 pm

I find it funny when you read the results on studies for new treatments for MS, it seems like they can never let go of the current approved treatments. Whats up with that? They always say "May be a possible treatment for MS in conjunction with current treatments Interferon Beta-1a". Its like the makers of CRAB pay for advertising in clinical studies. Give it up already. It was good for what it was, but its time to move on! We need better treatments, and answers.
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Postby Sharon » Fri Dec 02, 2005 1:52 pm

Just as an FYI to everyone -

Those who have an allergy to sulfa compounds need to be careful in using the combination glucosamine/chondroitin.
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Postby Brownsfan » Tue Dec 06, 2005 6:30 am

Anyone know if the Chondroitin is necessary or is the glucosamine effective by itself? Definitely cheaper without the chrondroitin.

thanks!
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Postby dignan » Tue Dec 06, 2005 7:46 am

Chondroitin isn't necessary for the EAE benefits they found. Everybody should remember that there is absolutely no evidence that glucosamine helps humans with MS...but if you're a rat with EAE, you should rush out and get some right away!
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Postby gkalman » Wed Dec 07, 2005 7:45 am

Funny. If you are a rat with EAE, you have nothing to worry about because there are at least 20 things out there with essentially 100% effectiveness. Wouldn't even need to bother with glucosamine.
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