List of current drug trials

A board to discuss future MS therapies in early stage (Phase I or II) trials.

List of current drug trials

Postby Kasuku » Tue Dec 13, 2005 10:19 am

I saw this list on another MS board forum. I am sorry if this is a repeat. It was first available in September, therefore, they are probably new drugs to be added. The credit for putting this list together should go to Jay.

"MS Disease-Modifying Meds"

( Approved Meds )

1. Avonex (interferon beta 1a)
2. Betaseron (interferon beta 1b)
3. Copaxone (glatiramir acetate)
4. Novantrone (mitoxantrone)
5. Rebif (interferon beta 1a)

Treatments ( not ) approved for MS but used “off label”

1. Azathioprine (aka Imuran)
2. Cyclophosphamide (aka Cytoxan)
3. Doxycycline, Amoxicillin, Rifampin, Metronidazole (Vanderbilt protocol)
4. Doxycycline, Roxithromycin, Metronidazole (David Wheldon protocol)
5. Intravenous Immune Globulin (IVIg)
6. LDN
7. Methotrexate
8. Mycophenolate mofetil (aka Cellcept)
9. Plasma exchange (aka plasmapheresis)

( Meds In Phase III Trials )

1. Betaseron (500 mcg dose)
2. FTY720 (Novartis)
3. Laquinimod (aka ABR-215062) (Teva)
4. MBP8298 (BioMS) (trial for SPMS)
5. Mylinax (oral cladribine) (Serono)
6. Progestin and Estradiol (Hospices Civils de Lyon)
7. Rebif (fetal bovine serum-free/human serum albumin-free) (Serono)
8. Stem cells - autologous hematopoietic
9. Teriflunomide (aka HMR 1726) (Sanofi-Aventis)
10. Tysabri (natalizumab) (Biogen / Elan)

( Meds In Phase II Trials )

1. ABT-874 (Abbott)
2. Aimspro (suspended) (Daval)
3. Albuterol (aka Proventil) (with Copaxone)
4. Alferon N Injection
5. Alpha lipoic acid
6. BG12 (aka Fumaderm)
7. Campath (aka alemtuzumab) (Genzyme)
8. CNTO1275 (Centocor)
9. Daclizumab (aka Zenapax) (Protein Design Labs, Biogen-Idec)
10. Doxycycline (with Avonex)
11. E2007 (Eisai)
12. Fludarabine phosphate (aka Fludara) (with Avonex)
13. Inosine
14. Interferon enhancing therapy (aka EMZ701) (Transition Therapeutics)
15. Interferon-tau (aka tauferon) (Pepgen)
16. Lamotrigine (Lamictal) (Glaxosmithkline)
17. Lipitor (aka atorvastatin) (Pfizer)
18. Mesopram (Berlex)
19. Minocyline (with copaxone)
20. MLN1202 (Millenium)
21. MN-166 (aka ibudilast and Ketas) (Medicinova)
22. N-acetyl-L-cysteine (with copaxone)
23. NBI-5788 (Neurocrine)
24. Neruovax (Immune Response Corp)
25. Omega 3 Fatty Acids (completed)
26. Oral glatiramir acetate (aka Copaxone) (Teva)
27. Pioglitazone (Actos)
28. Pirfenidone (aka Deskar) (Intermune) (trial for SPMS complete)
29. Pixantrone (aka BBR 2778) (Cell Therapeutics)
30. RO0506997 (Hoffmann-La Roche)
31. Rituxan (Biogen) (for PPMS and SPMS)
32. Rosiglitazone (aka Avandia)
33. Sirolimus (aka Rapamune)
34. Temsirolimus (CCI-779) (Wyeth)
35. Testosterone
36. Topiramate (aka Topamax) (with Avonex)
37. Tovaxin (Pharmafrontiers) (completed?)
38. TV-5010 (Teva)
39. Xaliproden (SR 57746) (Sanofi-Aventis)
40. Zocor (aka simvastatin) (Merck)

( Meds In Phase I Trials )
1. AL-108 (Allon)
2. AZD4750 (Astra Zeneca)
3. AVE9897 (Sanofi-Aventis)
4. BHT-3009-01 (Bayhill Therapeutics) (with Lipitor)
5. C6448 (Merck)
6. Cannabinor (Pharmos)
7. CDP323 (Celltech)
8. ciliary neurotrophic factor (aka CNTF)
9. CTLA4-Ig (Repligen)
10. DADMe-Immunicillin-H (Albert Einstein College of Medicine)
11. Gemfibrozil (aka Lopid)
12. Genz 29155 (Genzyme)
13. JNK Inhibitor (Serono)
14. MDX1100 (Medarex)
15. MLN 3897 (Aventis)
16. MMP-12 Inhibitor (Serono)
17. Plasma exchange (aka plasmapheresis) (completed?)
18. RG2007 (aka CTLA4-IgG4m) (Immune Tolerance Network)
19. Riluzole (ALS drug) (completed)
20. Sildenafil Citrate (aka Viagra)
21. Treosulfan (for SPMS)
22. TV-3606 (Teva)
23. Vitamin D3 (with calcium) (St. Michael's Hospital - Toronto)
24. ZK811752 (Schering)

( Pre-Clinical )

1. AZD 5904 (Astrazeneca)
2. AZD 8797 (Astrazeneca)
3. Erythropoietin (aka EPO)
4. Glial Growth Factor 2 (aka GGF2) (Acorda)
5. Neurodur (Ceptor)
6. NNZ-2566 (Neuren)
7. Osteopontin (Serono)
8. PXS64 (Pharmaxis)
9. ROB 895 (Oxypharma)
10. RPI-78M (Nutra Pharma)
11. ShK(L5) (UC Irvine)
12. sTNFR:Fc/p80 (Medical University of Lodz, Poland)
13. tetracyline (non-antibacterial) (Paratek)
14. Vasoactive Intestinal Peptide (aka VIP)
15. Vitamin B12 (Hospital for Sick Children - Toronto)

===== End =====

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Postby dignan » Tue Dec 13, 2005 1:18 pm

It's actually a list from ThisISMS originally. It's located in the "Drug Pipeline" forum. The title of the thread is "Summary of the pipeline". It was something that I started in early August and that a bunch of other people here have contributed to over the last few months. I'm glad to see it has made its way to other MS boards. That's the idea, get the information out there for all to see.

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