Neurosteroids

A board to discuss future MS therapies in early stage (Phase I or II) trials.

Neurosteroids

Postby Liberation » Wed Feb 06, 2013 7:34 am

It is older story, but might merit more attention as hormon levels can be adjusted even without a new drug:

"Studies in EAE mice showed reduced neurosteroid levels in their brains. Intraperitoneal
injections of allopregnanolone in mice shortly after induction of EAE led to improvements in several
markers of disease, relative to sham-treated animals.

These included:
Preserved myelin in the spinal cord
Reduced reactivity in immune cells
Lower immunoreactive cell counts in the spinal cord
Reduced axonal injury
75% reduction in clinical disease severity scores"

http://www.medpagetoday.com/clinical-co ... osis/28655
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