Testosterone

A board to discuss future MS therapies in early stage (Phase I or II) trials.

Testosterone

Postby Kronk » Wed Dec 11, 2013 3:44 pm

Testosterone in women with MS is significantly lower than a healthy subject. On the flip side of this too much testosterone in a female MS patient causes irreversible brain damage during a relapse. This is why it is thought that while men get MS less often they typically have a more progressive and debilitating form of it.

The sex hormone level results were different for the men with little change between controls and MS patients. Testosterone didn't affect the men's results. Instead, estradiol, which is the result of conversion from testosterone to estrogen, was important. Men with multiple sclerosis and the highest estradiol levels had a greater degree of brain tissue damage.

I started reading about the benefits of testosterone and multiple sclerosis a while back with numerous studies proving it has a positive effect on brain shrinkage and memory. I jumped on the bandwagon and bought a 2 months supply of a natural PROVEN testosterone booster. But now it appears an anti aromatase product would have been a wiser purchase…

http://onlinelibrary.wiley.com/doi/10.1 ... ated=false

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Re: Testosterone

Postby NHE » Thu Dec 12, 2013 1:05 am

Kronk wrote:I started reading about the benefits of testosterone and multiple sclerosis a while back with numerous studies proving it has a positive effect on brain shrinkage and memory. I jumped on the bandwagon and bought a 2 months supply of a natural PROVEN testosterone booster. But now it appears an anti aromatase product would have been a wiser purchase…


I have a family member that was on the aromatase inhibitor Arimidex for treatment of breast cancer. She was on it for a total of 3 years (standard treatment protocol is 5 years) and had to stop due to the development of severe osteoarthritis. She had a hip replacement last summer and is now due for a full knee replacement. A search through the PubMed database revealed that osteoarthritis is a known side effect of Arimidex. Mushrooms contain natural aromatase inhibitors and might be safer than pharmaceutical ones. Eat 10g/day which is just one white button mushroom.
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Re: Testosterone

Postby Kronk » Thu Dec 12, 2013 8:48 am

Very good point. Lowering estrogen is known to cause joint pain and can lead to issues long term. Most manufacturers dont suggest using an anti-aromitase product for longer than 8 weeks. I plan on stacking it with Cissus Quadrangularis and limiting to 4 to 6 weeks max. Again this is just a trial, if I feel like garbage while on it I will discontinue. Just trying to find a balance with this disease and the research on testosterone makes it something to try.
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