This Is MS Multiple Sclerosis Community: Knowledge & Support

Welcome to the world's leading forum on Multiple Sclerosis research, support, and knowledge. For over 10 years, This is MS has provided an unbiased community dedicated to Multiple Sclerosis patients, caregivers, and affected loved ones.
It is currently Wed Jun 19, 2013 9:45 pm


All times are UTC - 8 hours [ DST ]




Post new topic Reply to topic  [ 1 post ] 
Author Message
PostPosted: Mon May 12, 2008 4:11 pm 
Offline
Family Elder
User avatar

Joined: Thu Jan 17, 2008 4:00 pm
Posts: 367
Both of these could benefit MS down the line.

Modulation of RNA Splicing Focuses on Inflammatory Diseases, Including Rheumatoid Arthritis

In this study, treatment with LNA oligonucleotides, developed by Santaris, induced alternative RNA splicing of TNF receptor 2, resulting in a switch from the membrane-bound to a soluble protein form, thus creating a "decoy" receptor, which accumulated in the circulation of treated mice. The generated soluble TNF receptor protein antagonized TNF-alpha, interfered with its inflammatory function, and reduced severity of inflammatory disease in mouse models of hepatitis and arthritis. This is the first report of upregulation of the endogenous, circulating TNF-alpha antagonist by oligonucleotide-induced modulation of splicing.

Presentation of Phase 1 Clinical Data of MDX-1100

MDX-1100 is a fully human antibody that targets CXCL10 (also known as
IP-10), a chemokine expressed in association with multiple inflammatory
disease indications such as rheumatoid arthritis, inflammatory bowel
disease and multiple sclerosis.


Top
 Profile  
 
Display posts from previous:  Sort by  
Post new topic Reply to topic  [ 1 post ] 

All times are UTC - 8 hours [ DST ]


Related topics
 Topics   Author   Replies   Views   Last post 
There are no new unread posts for this topic. MS drugs

bromley

4

1852

Thu Jan 12, 2006 6:56 pm

dignan View the latest post

There are no new unread posts for this topic. Article on MS drugs

bromley

0

1322

Sat Oct 08, 2005 1:04 pm

bromley View the latest post

There are no new unread posts for this topic. Overview of drugs

bromley

0

1294

Tue Mar 14, 2006 2:46 pm

bromley View the latest post

There are no new unread posts for this topic. Allon drugs

bromley

0

1110

Fri May 19, 2006 8:44 am

bromley View the latest post

There are no new unread posts for this topic. Article of MS drugs

bromley

1

1228

Fri Sep 15, 2006 8:32 am

dignan View the latest post

 


Who is online

Users browsing this forum: No registered users


You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum

Search for:
Jump to:  


News News Site map Site map SitemapIndex SitemapIndex RSS Feed RSS Feed Channel list Channel list
Read hundreds of personal Multiple Sclerosis stories on Experience Project. Experience Project is an anonymous community where people connect through their life experiences, made by the same people who built This is MS. With over 30 million personal stories about every possible life experience, you can quickly find people like you!


Interesting: Secret Confessions | Dream Meanings | Ask Questions, Get Answers

Advertise on the premier multiple sclerosis forum