Calpain inhibitor

A board to discuss future MS therapies in early stage (Phase I or II) trials.

Calpain inhibitor

Postby bromley » Tue Aug 05, 2008 3:10 am

Contain your excitement because it's yet to be tested on humans. But it's "novel" and "oral".

Ian


Novel calpain inhibitor inhibits the progress of multiple sclerosis (MS) in an animal model 05 August 2008

Researchers at SUNY Downstate Medical Center have developed a substance that inhibits the progress of multiple sclerosis (MS) in an animal model. The agent, a novel calpain inhibitor, can be administered orally.

Calpains are a family of proteolytic enzymes naturally found in the human body. Inappropriate activation of calpain is associated with a number of neurodegenerative and autoimmune diseases such as multiple sclerosis. It is known to destroy the myelin sheath that coats and protects the nerves.

In a paper published in the Journal of Neuroimmunology, SUNY Downstate and Maimonides Medical Center researchers described the use of the calpain inhibitor for the treatment of a mouse model of MS. Whether administered by injection or by mouth, the inhibitor produced an almost complete cessation of the disease’s progress.

The calpain inhibitor, developed at Downstate, was shown to reduce clinical illness signs and prevent demyelination and inflammatory infiltration in a dose- and time-dependant manner, and holds promise in treating both the acute and chronic phases of MS. The inhibitor may also prove beneficial for treating other degenerative illnesses, such as Alzheimer’s, Huntington’s and Parkinson’s disease.

Source: Health Article © 2008 - Health Article News
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Postby Terry » Tue Aug 05, 2008 5:23 am

Thanks for posting this. I have recently started taking simple digestive enzymes on an empty stomach. When eating, the enzymes help digest food. When the stomach is empty, the enzymes find their way into the blood stream. I guess I got stuck on the "MS as a vascular disease thing".
The enzymes clear away fibers and clots, etc. You can read some here- just found this, but this is not from the reading that made me decide to try this. Lost that.


http://www.nutritionalwellness.com/archives/2006/jul/07_proteolytic.php
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