A board to discuss future MS therapies in early stage (Phase I or II) trials.

Re: lisinopril

Postby Jimpsull » Fri Jun 07, 2013 10:38 pm

Phase II Clinical Trial About to Begin using Lisinopril in MS:
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Re: lisinopril

Postby AdiosMS » Sat Dec 21, 2013 12:43 pm

Very interesting. I was on lisinopril for HBP for years until I developed the dry cough. During that time, I had no MS symptoms or was even aware I had MS. Apx. 4 years ago, I switched to Benicar. All was well until apx. 15 months ago, when I had left-sided short-term paralysis & was diagnosed with MS via MRI, CAT scan. I went into remission after apx. 6 weeks, then apx. 5 months ago, I had a milder relapse with again left-sided weakness.
I would be interested to follow the lisinopril research.
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Re: lisinopril

Postby NHE » Sat Dec 21, 2013 5:14 pm

In this study...

Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity

...the EAE mice were dosed with lisinopril at 10 mg/kg/day. That's about 60x the dosage normally given to a person with high blood pressure.

Is a dosage this high physiologically relevant?
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