lisinopril

A board to discuss future MS therapies in early stage (Phase I or II) trials.

Re: lisinopril

Postby Jimpsull » Fri Jun 07, 2013 10:38 pm

Phase II Clinical Trial About to Begin using Lisinopril in MS:

http://www.transparencyls.com/?q=node/23
Jimpsull
Family Member
 
Posts: 67
Joined: Thu May 16, 2013 8:49 pm

Advertisement

Re: lisinopril

Postby AdiosMS » Sat Dec 21, 2013 12:43 pm

Very interesting. I was on lisinopril for HBP for years until I developed the dry cough. During that time, I had no MS symptoms or was even aware I had MS. Apx. 4 years ago, I switched to Benicar. All was well until apx. 15 months ago, when I had left-sided short-term paralysis & was diagnosed with MS via MRI, CAT scan. I went into remission after apx. 6 weeks, then apx. 5 months ago, I had a milder relapse with again left-sided weakness.
I would be interested to follow the lisinopril research.
AdiosMS
Getting to Know You...
 
Posts: 14
Joined: Sat Sep 07, 2013 3:58 pm

Re: lisinopril

Postby NHE » Sat Dec 21, 2013 5:14 pm

In this study...

Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity
http://www.pnas.org/content/106/35/14948.full.pdf

...the EAE mice were dosed with lisinopril at 10 mg/kg/day. That's about 60x the dosage normally given to a person with high blood pressure.

Is a dosage this high physiologically relevant?
User avatar
NHE
Volunteer Moderator
 
Posts: 3355
Joined: Sat Nov 20, 2004 4:00 pm

Previous

Return to Drug Pipeline

Who is online

Users browsing this forum: No registered users


Contact us | Terms of Service