This Is MS Multiple Sclerosis Community: Knowledge & Support

Hi,

My husband is on the clinical trial for the FTY720 (he is PPMS).
He started January 14 2009. (The Netherlands)
The dosis was 1,25 mg, but today they told us de new dosis will be 0,75 mg.
Does anyone know if there is a reason for that?

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My husband, Rob, has PPMS, diagnosed august 2006, EDSS score 5.0. He is on the new FTY 720 trial, phase III since January 2009. We are from The Netherlands

Astrid, there has been some discussion here about this trial. It appears that the 0.5 mg dose is just as effective as the 1.25 mg dose for RRMS patients, and the side-effect profile is better, so Novartis is moving to the lower dose to enhance safety, I think. Here are the threads where it has been discussed:

Thread specifically about PPMS study: http://www.thisisms.com/ftopicp-57604.html

Thread about latest fingolimod RRMS results: http://www.thisisms.com/ftopict-8306.html

Another thread about latest fingolimod RRMS results: http://www.thisisms.com/ftopicp-69429.html

Hi Astrid and others following the FTY 720 trial for PPMS,

I was contacted yesterday via e-mail by my neurologist's office and told that
Novartis has put a halt on screening any new participants for this trial globally. Wonder why?

I hope it is because the drug works and Novartis anticipates being able to get it on the market soon but.... realistically I realize it could be because they think it does not work for PPMS.

What do you think?

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Primary Progressive, Onset 10 years ago at age 42, diagnosis 6 years ago, Vit D, Chinese Herbs, Exercise, yoga. So far tried antibiotics, fumaric acid and 4AP. Currently participant in the FTY720/PPMS Trial.<br />

Hi Smiling Face

I'm not really following FTY 720 for PPMS but am aware of this research brief and wonder if they might be re-grouping in light of CCSVI? It's a really wild guess.

Interleukin-17 and brain injury in stroke


Take care

Sharon