T lymphocytes that collect at infarction zones within 24 h of a stroke have been suggested to have an important role in the progression of cerebral ischemia– reperfusion (i–r) injury
Use of FTY 720, an immunomodulatory prodrug, to block infiltration of T lymphocytes into the brains of mice just after the induction of the brain infarct reduced brain damage compared with controls.
‘‘…this could be the first successful therapy in the subacute phase of brain infarction after stroke’’
This study suggests several new potential therapeutic pathways that could help to reduce the secondary inflammation after stroke that promotes brain damage...
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