I have researched the ANA question as it relates to MS and I found that ANA is elavated in about 25% of active MS folks.
This make it especially difficult to use it as way to distinguish MS from Lupus and other neurological conditions.
Neurology. 1997 Sep;49(3):857-61.
Frequency and significance of antinuclear antibodies in multiple sclerosis.
Collard RC, Koehler RP, Mattson DH.
Department of Neurology, University of Rochester School of Medicine and Dentistry, NY, USA.
Neurology. 1998 Aug;51(2):650.
In a prospective sample of patients with multiple sclerosis (MS) we found a high frequency of antinuclear antibodies (ANA), 22.5%, confirming results from previous studies.
ANA occurrence did not correlate with gender, age, duration of MS, MS course, or disability in either the prospective and retrospective samples of MS patients.
In 16 patients with MS tested at two time points, ANA occurrence did correlate with MS disease activity. This suggests that the high frequency of ANA in MS reflects ongoing immune dysregulation.
PMID: 9305354 [PubMed - indexed for MEDLINE