Test # 1
After a 12 hour fast, measure Total Iron Binding Capacity (TIBC) and the Serum Iron (SI). To achieve the percentage of Saturation you divide the TIBC into SI..
Serum Iron (SI)/Total Iron Binding Capacity (TIBC) = Transferrin Saturation (TS)
Safe range = 12-44%
Total iron-binding capacity (TIBC) is most frequently used along with a serum iron test to evaluate people suspected of having either iron deficiency or iron overload. These two tests are used to calculate the transferrin saturation, a more useful indicator of iron status than just iron or TIBC alone. In healthy people, about 20-40% of available sites in transferrin are used to transport iron.
In iron deficiency, the iron level is low, but the TIBC is increased, thus transferrin saturation becomes very low. In iron overload states, such as hemochromatosis, the iron level will be high and the TIBC will be low or normal, causing the transferrin saturation to increase.
Recommended laboratory tests for the workup of a patient you suspect may have hemochromatosis are
Fasting transferrin saturation test (TS)
SI and either TIBC or UIBC are usually used to calculate TS.
TS = (SI / TIBC) X 100
TS = (SI / (SI + UIBC)) X 100
Serum ferritin test (SF)
*at least in this case it is stated right out in plain view that the normal range sucks!Normal Results
Male: 12-300 ng/mL
Female: 12-150 ng/mL
The lower the ferritin level, even within the "normal" range, the more likely it is that the patient does not have enough iron.*
Normal value ranges may vary slightly among different laboratories...
Clinical Laboratory Tests
Ferritin 10-250 µg/L
<18 probably iron deficient
18-40 possibly deficient
41-100 probably not deficient
101-300 not iron deficient
>300 possible iron overload
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