I take Extra thingies to lower Gamma Interferon levels in the fall, winter and very early spring.
The Gamma Interferon connection is well known and well documented.
I have noticed that the effects (lesions and symptoms) do not occur immediately but seem to show up in my case in the Jan/Feb/March time frame.
Neurology. 2002 Apr 9;58(7):1077-80.
Seasonal variation in immune measurements and MRI markers of disease activity in MS.
Killestein J, Rep MH, Meilof JF, Adèr HJ, Uitdehaag BM, Barkhof F, van Lier RA, Polman CH.
Department of Neurology, VU Medical Center, Amsterdam, The Netherlands. J.Killstein@vumc.edu
BACKGROUND: The exact mechanisms by which T cells contribute to MS progression are not known. Recently, the results of cross-sectional studies suggested seasonal variation of both interferon (IFN)-gamma production and the number of active MRI lesions in MS.
OBJECTIVE: To investigate whether seasonal fluctuations of IFN-gamma and active MRI lesions could be confirmed and whether any correlations could be detected.
METHODS: Data were analyzed from a group of 28 MS patients in whom detailed longitudinal monitoring of both immune function and MRI measurements had taken place.
RESULTS: Significant seasonal variation was observed in T-cell activation as measured by the ability of T cells to secrete the pro-inflammatory cytokines tumor necrosis factor-alpha and IFN-gamma. Maximum values were found in samples obtained during autumn. Even though clear fluctuations were observed, no significant seasonal variation could be detected in the number of active MRI lesions. Fluctuations of in vitro IFN-gamma secretion correlated weakly with changes in active MRI lesions.
CONCLUSIONS: The finding of seasonal variation of immune function in serially MRI-monitored MS patients suggests an environmental role in T-cell activation.
PMID: 11940696 [PubMed - indexed for MEDLINE]