.Immune system enzyme flaw may determine degree of MS

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.Immune system enzyme flaw may determine degree of MS

Postby MSUK » Mon Oct 11, 2010 7:50 am

.Immune system enzyme flaw may determine degree of MS severity


A thesis from the Sahlgrenska Academy concluded that a flaw in one of the immune system's enzymes determines the degree of the severity of autoimmune diseases like multiple sclerosis (MS) and Guillain-Barré syndrome (GBS).

These new findings can explain the way that this enzyme deficiency can be diagnosed and also why these diseases can vary so much.
The immune system is based on white blood cells, that play a vital role in fighting against pathogens.

The white blood cells contain an enzyme that transforms oxygen into reactive oxygen radicals – which break down microorganisms and stop infections, called NADPH oxidase.

These new studies have used animal models to show that an inadequate production of oxygen radicals can favor the development of autoimmune diseases, as the patient's immune system would attack itself....Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1100
MS-UK - http://www.ms-uk.org/
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Postby LR1234 » Mon Oct 11, 2010 8:35 am

http://bloodjournal.hematologylibrary.o ... /93/5/1464

This gives more info on NADPH.

I have come across a couple of articles relating NADPH oxidase and the vascular system as well as autoimmune disease.....hopefully we are getting closer to finding more links of the vascular system and immune system in MS.

If someone could explain NADPH oxidase's role more clearly to me and how it affects the vascular system and the immune system I would appreciate it as I can't quite get my head around it all!!!

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