Lyon wrote:The theory was untested, but it seemed to explain an unexpected observation in another patient with severe aplastic anemia (SAA)—a 19-year-old who had received HiCy to prepare him for a bone marrow transplant from his sister the year before. The transplant hadn’t taken. As his blood counts recovered post-transplant, they were not his sister’s cells, they were 100 percent male, his own cells—but they had recovered. Perhaps, Sensenbrenner mused, cyclophosphamide alone was responsible for the cure.
Sorry for hijacking your thread, msmything....
This is an interesting paragraph. Cyclophosphamide sounds familiar to me... maybe it is what was used on my brother as well. I know that the procedure we went through was used for aplastic anaemia px as well. His transplant was done in Toronto when bone marrow transplants were brand new to Canada - in fact we thought we were probably going to the US when they first started typing us family members for a match. They told us that his marrow would now have female chromosomes because his donor was female (that's xx, I think), where the rest of his body is xy, so that one day if he were to develop leukemia again, it would be interesting to know if the leukemic cells were XY. This would indicate that cells were missed in the chemo/radiation procedure. If there was new leukemic cells that were xx (mine from the transplant), then they could deduct from that - something within his body chemistry just says he will have leukemia. I found this very interesting at the time. He survived the transplant, although had some real GVH issues. Just after a year (the magic date that should have meant that the transplant was successful), he started developing tumors near his spine & in his brain. The tumors in his spine were comprised of leukemic cells. Leukemia will metastasize in that way, we were told & go to protected areas.... I asked the question when this happened - are these cells XX or XY and the doctors at the Hospital in Saskatchewan looked at me like I just grew another eye. I was disappointed that scientifically, this was never questioned by the medical brains & we will never know. He passed away due to complications from the treatments he was receiving to shrink those tumors.
In the transplant process - it was explained to us that the chemo/radiation courses worked on a timing basis, so that the marrow he received from me would start re-growing all the while his own marrow was being destroyed, there may be an overlap in that timed release process of destroying his. I had to stay in the area until they knew he had new cell growth. For about a week after his transplant I was going every day to some cell separating machine in the hospital, where they pulled platelets from me to transfuse into my brother because his platelet count was threatened.