NHE, ever had your magnesium level checked?
acar, i am looking up postural neuropathic pain. here's what i've found so far:
•Atherosclerosis is the progressive narrowing and hardening of the arteries, which is caused by aging as well as other factors. As the condition worsens, pain or burning sensations can be felt in the lower extremities. These occur when a person is lying down. This resting leg pain is worse when lying down because blocked arteries in the leg do not allow sufficient blood flow to the feet and toes. To relieve this pain, the sufferer might have to hang his legs off the side of a bed
At Rest Leg Pain At Night
•Sometimes a person might get a leg cramp while resting in bed. It can be an uncontrollable spasm of a calf muscle and the pain can range from mild to severe. These attacks can be chronic for some individuals or an occasional occurrence for others. While they might happen for unknown reasons, it is known that dehydration, as well as certain medications, can cause resting leg pain. Leg cramps can also be the sign of more serious problems, such as atherosclerosis or thyroid disease.
given these search results, you may want to investigate your magnesium, zinc and vitamin E status
to see if those could be contributing your leg pain when lying down.
also, C reactive protein
accelerates atherosclerosis so you might want to have a look at that level too.
both magnesium and vit E bring down C reactive protein levels.
vit E is low in MS
patients during exacerbation. interferon helps boost vit E
levels (never mind just getting enough dietary vit E
to optimize your levels of mag zinc and E, aim for the averages seen in 'healthy controls' in studies comparing nutritional status in health and disease (doesn't matter what disease).
this approach gets you a much narrower and effective target range as opposed to accepting that your levels are 'normal' (from what i've seen to date, 'normal' only means stats normal - to get an abnormal result you have to have THE lowest or THE highest result ever seen at your lab before!)
established in the literature:
*you want your magnesium level to be at least 0.91 mmol/L
*zinc should be around 18 umol/L (17 to 19 is ok)
*vitamin E status probably around 26 mmol/L
(NB vit E is tougher - there are 8 components to the complex but in my experience most labs only offer alpha-tocopherol testing).
Vit E health and disease studies:
Int J Adolesc Med Health. 2007 Apr-Jun;19(2):177-86.
Biochemical assessments of retinol, alpha-tocopherol, ...in adolescent professional basketball players and sedentary controls.
...all plasma vitamin levels were significantly higher in basketball players (...vitamin E: 26.45 +/- 0.72 mmol/l
, ...) than sedentary controls (...vitamin E: 19.24 +/- 0.73 mmol/l ...) (p < 0.01).
Alpha tocopherol (mmol/l) (Ranges)
MS patients 22.05 ^ 2.05* (16.74–25.31)
Healthy Controls 26.20
^ 1.99 (21.44–33.28)
from this set of studies i'm taking away that mid-high vit E is optimal.
just a tidbit on the differences between vit E complex components:
J Intern Med. 1996 Feb;239(2):111-7.
Gamma, but not alpha, tocopherol levels in serum are reduced in coronary heart disease patients
fyi most commercial vit E supplements are just alpha-tocopherol. taking just alpha-tocopherol actually drives down gamma tocopherol
, changes the natural alpha/gamma ratio.
gamma tocopherol has a number of important contributions to health, not just heart disease but as a tumor suppressant.
dark leafy greens and raw sunflower seeds
are good whole food dietary choices for augmenting vit E status.
more info: http://www.whfoods.com/genpage.php?tnam ... oodsources
hope that helps!
my approach: no meds so far - just nutrient-dense anti-inflammatory whole foods, and supplements where needed
info: www.whfoods.com, www.nutritiondata.com