progesterone and MS

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Re: progesterone and MS

Postby Liberation » Mon Jan 16, 2012 3:09 am

thanks for the posts, ikulo. They are really great. As a male, I am just wondering what I can do with these hormones. Is there any reference level of the sex hormones for a male? What level should we target? What could be the side effects of using a natural progesterone cream for a male?

It would be good to talk to a doctor, but neurologists are really against doing anything other than prescribing the usual drugs, while other doctors just do not want to interfere as it is ms.

I am also just wondering what are the other ways of increaing the neurosteroid level (like allopregnanolone)?
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Re: progesterone and MS

Postby ikulo » Mon Jan 16, 2012 5:34 pm

Hey Lib,

I haven't done enough research on the reference levels. I just got new health insurance so I haven't been able to get to a doc to check levels. I'm hoping to get into a naturopath sometime soon to get my levels checked, naturopaths seem to be more open toward hormones, herbals, etc. Will keep you posted.
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Re: progesterone and MS

Postby SaraG » Tue Jan 24, 2012 5:10 pm

I have been on the Mirena IUD for 7 years. Before that I lost 2 pregnancies due to extremely low progesterone but had two children with treatment. When I was trying to figure out birth control my gyno suggested Mirena and told me it worked by somehow stimulating the body to make too much progesterone to allow fertilization. I quickly felt better and even though I was later diagnosed with MS (wit many many years of symptoms) I was loathe to have it removed because I really felt it had somehow helped me. Maybe, maybe not and purely anecdotal but I have felt very strongly that having it permanently removed would be a mistake for me. However, I am always hesitant to recommend it to friends because I have read some women have not liked it (possibly women who already make enough Progesterone end up with way too much?) Anyway, just thought I'd throw that out there.
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Re: progesterone and MS

Postby Shayk » Mon Feb 27, 2012 12:59 pm

Hi again

There's a new open access (free) article on progesterone :smile:

Progesterone Synthesis in the Nervous System: Implications for Myelination and Myelin Repair

If you're at all interested in progesterone I think it's well worth the read; there is a small section on MS and progesterone in the article.

And guys, you may be interested in this abstract: Progesterone: The Forgotten Hormone in Men?
Other progesterone effects in men include those on the central nervous system (CNS) (mainly mediated by 5alpha-reduced progesterone metabolites as so-called neurosteroids)

And in this commentary by Dr. John R Lee (now deceased) Hormone Balance in Males

And they wonder why people with MS lose the ability to remyelinate? Could it be in part due to declining hormone levels (including progesterone?) It's my understanding that in women at least progesterone levels start to decrease before estrogen levels start dropping.

Take care

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