I think that the vitamin D metabolism lies at the root of many inflammatory diseases, including MS. This article brings things together:http://www.discoverymedicine.com/Shaopi ... infection/
Of course, MS gives rise to various neurological symptoms and in our brains more (= multiple) sclerosis can be found. It is therefore obvious that the medical world looked at the problem from this viewpoint and called it multiple sclerosis. And also that therapies were developed from this angle. And because they did not know the origin of the disease, it was called autoimmune. But the path has brought us nowhere, on the contrary.
With this new insight, we come (much closer) to the origin of the disease. Although MS gives rise to neurological symptoms and scleroses, the disease is actually a metabolic disorder and would be better described by a different name, for instance chronic bowel disease. The Vitamin D metabolism lies at the heart of the problem, in particular the "contamination" of the vitamin D receptor by intestinal bacteria. And if one thinks about possible therapies, they should start from there.
The vitamin D metabolism has everything to do with the power of the cells. If the receptors are activated and the cells are well fed, they can move mountains, and they are well armed against intruders. But if they weaken because insufficient fuel is supplied, they will not work properly (including ion pump failure and thus weakening of neuro-transmission), they get easily infected, and eventually they will die a quiet death (apopth.. = controlled cell death).
The angle of attack of the disease would have to shift -besides tackling the vascular narrowings in the neck by angioplasty (re: ccsvi, Zamboni)- from immune-modulating (interferon works immune suppressive while anti-biotics stimulate/support ref: Marshall) to a more direct approach addressing the metabolic problem with the vitamin D receptor. I see two possibilities, that could possibly be used in combination: 1. by using olmesartan to sweep the receptors clean to make sure they can be activated (possibly in combination with anti-biotics), and/or; 2. by using metformin.
The working mechanism of metformin is not well understood, but fact is that it does work very well for diabetes2
. As such it has been suggested that metformin may help break down the seal of ultra bad MGmin cholesterol and thus open the gates (GLUTs) of the cells; that it may block the (dysfunctioning?) vitamin D receptor and some other receptors and help in that way; and that it may bind to cell receptors restoring insulin sensitivity to the cells and thus help overcome "subclinical" diabetes, a condition that most adults suffer from; incidently, then we'r back to the first posting of this thread that started by suggesting a double mechanism underlying MS as can be seen from the double peak in the graph of age of onset].
If the vitamin D metabolism is normalised, the cells are properly fed, there will be few to die, the ion pump is better charged and the neuro-transmission improves, and the immune system and many other regulatory pathways will calm down. The innate immune system (our first line of defense) with a direct relationship to vitamin D will return to normal. The stress on our shoulders will literally fade away and you get old slowly and smoothly….