This thread breaks with the existing believe that MS is an autoimmune disease and on the way we found that micro-cellular nutrition is key. We also found that cortisol is probably not so much inflammatory suppressive but rather improves (the conditions for) micro-cellular nutrition which in turn calms down the immune system. This is probably one of the biggest dogma's in the medical world that will need to be relinquished..
We must not fall into the same trap as the medical world has done, that is that we start to believe dogmatically in certain concepts and thinking, for instance about the good and bad T-cells (see above posting of 4 June on diseases that originate from the gut). We must keep sight of new sources of inspiration and reference, we must cherish the means and preconditions to reinvigorate the sense of plurality. To this end, it is probably useful to halt for a moment here and ask ourselves the question why the immune system gets it wrong. And whether it is really true that bad T-cells get out of our gut to do their damaging work or, alternatively, whether these T-cells are just normal T-cells that for one reason or another are misguided, for instance by a deficiency in the nutrition.
From references above, it has been seen that the faulty gut may be the cause of a vast array of "immune" diseases. For some, the bad T-cells get to the joints and do their destructive work there leading to rheumatic diseases, or to the lungs leading to asthma; for others, the bad T-cells get on the glucose gates of our cells in a wider sense leading to diabetes mellitus type 2 with collateral damage to our myelin and Schwann cells leading to neuropathy. If we consider this case on its merits, a thesis could well be defended that argues that the T-cells are perfectly normal and re-active but that they are misguided in some way, that this can happen in different places in the body depending on genetic susceptibilities and predisposition, and possibly that the glucose metabolism is central and holds the key...
And there is evidence that would also suggest that if the normal glucose metabolism is restored (one way to express this would be to say "the insulin sensitivity is enhanced" but it is probably more than that), the immune system will calm down, the "bad" T-cells will start to behave normal, and the "immune" disease will be overcome..
Last night I searched a bit on the working mechanism of Metformin, the most common drug for diabetes mellitus type 2. What we do know is that it is not well understood how the drug works. The drug was derived from an old folks wisdom on the beneficial effects of the French lilac for people with diabetes and many mechanisms have been suggested since, some of which you may find in earlier postings on this thread. So I searched for Metformin, the glucose metabolism and the gut. And guess what? There is a strong suggestion here that Metformin works via the gut, in fact on the composition of the gut microbiota, see http://www.trialregister.nl/trialreg/ad ... sp?TC=1775
Whow, this is big and would seem to bring things into line:
It would suggest a central role for the glucose metabolism originating from the gut and explain why people with a gut flora transplantation may recover from diabetes and from MS, why people with diabetes mellitus type 2 benefit from Metformin and the progression of neuropathy comes to a halt.. And why people with MS…. To all, think it over...
But there was more. The search also brought up this paper on Metformin-induced regulation of the intestinal D-glucose transporters:http://www.jpp.krakow.pl/journal/archiv ... rticle.pdf
We know that there is an important role for the gut and the liver in the glucose metabolism. The Million $ question now is: what is wrong with our glucose metabolism and probably related to this the fatty acid mechanism? What is it that misleads these T-cells? We know that it may be stopped by a new liver (re: Caucasian women with the new liver general-discussion-f1/topic6044.html
). This last paper may hold a clue and should be explored with urgency.