Microbiota definately plays a vital role in our health and it is a topic I've been looking at for a while.
Just as a bit of an exploration, not specifically related to MS, but parallels can be drawn from this example.
Helicobacter Pylori - an upper GI bacteria living in the mucosal lining of the stomach.
It has been associated with Gastric ulcers and stomach cancer and also the incidence of diabetes so we should erradicate it, so some researchers advocate, but wait.
It has also been associated with reduced risk of gastric reflux and oesophageal cancer.
Then there is the interrelationship it has with Leptin & Ghrelin and when it is erradicated there is an increase in BMI, people get fatter.
There is also some suggestion that it protects against Asthma and Allergies.
So what to do, do we erradicate or do we fecal transplant it, is it good or bad???
Well as always the answer is not as simple as one finding from a study, it needs to be looked at in the overall context of health and population.
Basically some 70-100,000 ybp we walked out of Africa with these little bugs in our gut, and in fact their genetics is providing more clues as to the routes we took, but anyway it has likely been with us since before the first Homo Sapien was born.
When we look at epidemiological data we find that it has a high infection rate in the developing world over 90% but low in the developed world somewhere in the order of 25-35% most likely due to the prolific use of antibiotics and obsession with hygene.
So if I was regular researcher I would conclude that there is an strong inverse corrolation between the infection rate with H Pylori and the incidence of MS & other chronic diseases, therefore infection with H Pylori may be an effective measure to guard against these diseases.
But I'm not, so my conclusion is, hmmm interesting, what else is this telling us.
Why is it sometimes harmful and why is it sometimes beneficial, well one of those controlling factors may well be diet, H Pylori, like many bacteria loves glucose (sugar, flour etc.) so could it be that our excessively glucose dependant diets are causing an overgrowth in those with H Pylori and leading to negative consequences. Those that have been looking specifically at Ancestral Diets are now concluding that all carbohydrates are not the same, consuming cellular carbohydrates like fruit & starchy tubers does not seem to result in the same poor health outcomes as consuming acellular carbohydrates like flour & processed sugar. I picked up this review article after following your last link:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402009/
When you compare Kitavans who also rely on a large carb intake in their diet, they do not have obesity or chronic disease and all their health markers are good, including leptin, yet even healthy looking individuals in the west have significant abnormalities in these markers.
There are obviously many other factors at play in terms of lifestyle etc., but there is no denying that the diet we have been presented by our Govt's, Medicine & corporate interests is far from optimal.
I love the whole USDA food pyramid that most people take as a nutritional recommendation, when you disect the acronym, it is United States Department of Agriculture, it is a summary of agricultural production to be sold to achieve the highest net profit, not a nutritional guide.
Here's a bunch of links on H Pylori, that I went through to extract some of this info.http://high-fat-nutrition.blogspot.com. ... ucose.htmlhttp://stochasticscientist.blogspot.com ... ylori.htmlhttp://www.doctorshealthpress.com/diabe ... o-diabeteshttp://www.sciencedaily.com/releases/20 ... 124650.htmhttp://www.ncbi.nlm.nih.gov/pubmed/20009392http://www.eje-online.org/content/158/3/323http://cancerpreventionresearch.aacrjou ... 5/308.fullhttps://www.mja.com.au/journal/2005/182 ... on-between
I am just an interested individual trying to crack the autoimmune nut.
Partner has Graves Disease, 5 years, showing good test results, looking forward to potential remission in the near future.
3 friends have MS, 1 just recently diagnosed, severity 7/10.