Research teams implicate GM-CSF in the pathogenesis of MS

If it's on your mind and it has to do with multiple sclerosis in any way, post it here.

Research teams implicate GM-CSF in the pathogenesis of MS

Postby MSUK » Mon Apr 25, 2011 12:28 am

Image

Two research teams have separately implicated the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) as playing a central role in the IL-23-driven neuroinflammatory process that occurs in autoimmune diseases such as multiple sclerosis.

The separate groups, led by scientists at Thomas Jefferson University in Philadelphia and the University of Zurich in Switzerland, have found that IL-23 induces IL-17-producing T helper cells (TH17) to express GM-CSF, and this cytokine plays a key role in their encephalitogenicity. The Thomas Jefferson team notes that although the role of GM-CSF in the pathology of multiple sclerosis is unknown, these latest studies in animal models suggest that blocking GM-CSF activity may represent a feasible therapeutic strategy for multiple sclerosis.... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1100
MS-UK - http://www.ms-uk.org/
User avatar
MSUK
Family Elder
 
Posts: 2158
Joined: Wed Oct 14, 2009 3:00 pm

Advertisement

Return to General Discussion

 


  • Related topics
    Replies
    Views
    Last post

Who is online

Users browsing this forum: No registered users


Contact us | Terms of Service