Roles of Anti-MOG antibodies in demyelinating diseases

If it's on your mind and it has to do with multiple sclerosis in any way, post it here.

Roles of Anti-MOG antibodies in demyelinating diseases

Postby MSUK » Wed May 18, 2011 1:21 am

Image

New research shows that a substantial proportion of patients with acute disseminated encephalomyelitis have serum antibodies against myelin oligodendrocyte glycoprotein. The relationship between these antibodies and other demyelinating disorders such as multiple sclerosis, however, remains unclear.

Two new articles1, 2 reassess the role of antibodies against myelin oligodendrocyte glycoprotein (MOG) in pediatric cases of neuroinflammatory demyelinating disease. The studies confirm that approximately 40% of children with acute disseminated encephalomyelitis (ADEM) display serum antibodies against MOG, whereas only a small percentage of cases of clinically isolated syndrome (CIS) or multiple sclerosis (MS) display these antibodies.1, 2, 3, 4, 5, 6 Various controls were essentially negative for this antibody specificity, suggesting that rather than being a secondary epiphenomenon of nervous system damage, the anti-MOG response may be mechanistically involved in the disease process.... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1100
MS-UK - http://www.ms-uk.org/
User avatar
MSUK
Family Elder
 
Posts: 2090
Joined: Wed Oct 14, 2009 3:00 pm

Advertisement

Return to General Discussion

 


  • Related topics
    Replies
    Views
    Last post

Who is online

Users browsing this forum: No registered users