Roles of Anti-MOG antibodies in demyelinating diseases

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Roles of Anti-MOG antibodies in demyelinating diseases

Postby MSUK » Wed May 18, 2011 1:21 am


New research shows that a substantial proportion of patients with acute disseminated encephalomyelitis have serum antibodies against myelin oligodendrocyte glycoprotein. The relationship between these antibodies and other demyelinating disorders such as multiple sclerosis, however, remains unclear.

Two new articles1, 2 reassess the role of antibodies against myelin oligodendrocyte glycoprotein (MOG) in pediatric cases of neuroinflammatory demyelinating disease. The studies confirm that approximately 40% of children with acute disseminated encephalomyelitis (ADEM) display serum antibodies against MOG, whereas only a small percentage of cases of clinically isolated syndrome (CIS) or multiple sclerosis (MS) display these antibodies.1, 2, 3, 4, 5, 6 Various controls were essentially negative for this antibody specificity, suggesting that rather than being a secondary epiphenomenon of nervous system damage, the anti-MOG response may be mechanistically involved in the disease process.... Read More - ... ageid/1100
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