Interesting stuff from an article about resveratrol and alzheimer's (see link)...
Marambaud and colleagues want to tweak resveratrol to make it a drug.
"We're going to take this natural compound as a scaffold and modify [it] chemically to make it more active and ... more stable," Marambaud says.
"It is known from previous studies that if you isolate, purify, or produce the compound directly and you inject it in mice, the compound is very rapidly degraded, mostly by the kidney system," he explains. "To use it as a drug like that is difficult."
Marambaud says his team has already developed a series of molecules that are 20 times more active than natural resveratrol in terms of reducing beta-amyloid protein.
Those molecules are already being tested on mice; tests will take six months to a year and will check for toxicity, Marambaud says.
He adds that resveratrol has been shown to have some "very interesting pharmacological effects" against herpes, some cancers, and possibly neurodegenerative diseases such as Huntington's.
http://www.webmd.com/content/Article/11 ... genumber=2