Lipids, LDL higher in those with greater disability

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Lipids, LDL higher in those with greater disability

Postby hope410 » Thu Oct 06, 2011 8:56 am

This is from the Buffalo people studying CCSVI.

Serum Lipid Profiles are Associated with Disability and MRI Outcomes in Multiple Sclerosis.

Authors Weinstock-Guttman B, Zivadinov R, Mahfooz N, Carl E, Drake A, Schneider J, Teter B, Hussein S, Mehta B, Weiskopf M, Durfee J, Bergsland N, Ramanathan M.

Journal J Neuroinflammation.

2011 Oct 4;8(1):127. [Epub ahead of print] Affiliation

ABSTRACT:

BACKGROUND: The breakdown of the blood-brain-barrier vascular endothelium is critical for entry of immune cells into the MS brain.

Vascular co-morbidities are associated with increased risk of progression.

Dyslipidemia, elevated LDL and reduced HDL may increase progression by activating inflammatory processes at the vascular endothelium.

OBJECTIVE: To assess the associations of serum lipid profile variables (triglycerides, high and low density lipoproteins (HDL, LDL) and total cholesterol) with disability and MRI measures in multiple sclerosis (MS).

METHODS: This study included 492 MS patients (age: 47.1 +/- 10.8 years; disease duration: 12.8 +/- 10.1 years) with baseline and follow-up Expanded Disability Status Score (EDSS) assessments after a mean period of 2.2 +/- 1.0 years. The associations of baseline lipid profile variables with disability changes were assessed.

Quantitative MRI findings at baseline were available for 210 patients.

RESULTS: EDSS worsening was associated with higher baseline LDL (p = 0.006) and total cholesterol (p = 0.001, 0.008) levels, with trends for higher triglyceride (p = 0.025); HDL was not associated. A similar pattern was found for MSSS worsening.

Higher HDL levels (p < 0.001) were associated with lower contrast-enhancing lesion volume. Higher total cholesterol was associated with a trend for lower brain parenchymal fraction (p = 0.033).

CONCLUSIONS: Serum lipid profile has modest effects on disease progression in MS. Worsening disability is associated with higher levels of LDL, total cholesterol and triglycerides. Higher HDL is associated with lower levels of acute inflammatory activity.

PMID 21970791 [PubMed - as supplied by publisher]
Standard PubMed • NIH/NLM • NCBI • Copyright •

http://www.ncbi.nlm.nih.gov/pubmed/21970791
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Re: Lipids, LDL higher in those with greater disability

Postby chrishasms » Wed Oct 19, 2011 12:46 pm

I'm a 6+ EDSS. Was just dx'd with pre osteoporosis which is normal for that EDSS and I am just a little high on bad Cholesterol so I am on Lipitor now.

Good find. Doesn't help me but good find lolol
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Re: Lipids, LDL higher in those with greater disability

Postby jackD » Wed Oct 19, 2011 5:13 pm

I really HATE to mention it BUT you can raise HDL.

I raised mine from 41 to 76.

I did it via CURCUMIN with BIOPERINE or BCM-95, AND PYCNOGENOL AND ASTAXANTHIN.

I did it in stages. I also believe that taking TOCOTRIENOLS and Pomegranate juice and Pomegranate extracts supplements helped.

I was very recently in the hospital(60 days) and was told my arteries were now 100% clean. High HDL will do that. I still have a Stent from the old days when I was 90%+ clogged.

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