Neurology. 1997 Sep;49(3):857-61.
Frequency and significance of antinuclear antibodies in multiple sclerosis.Collard RC, Koehler RP, Mattson DH.
SourceDepartment of Neurology, University of Rochester School of Medicine and Dentistry, NY, USA.
In a prospective sample of patients with multiple sclerosis (MS) we found a high frequency of antinuclear antibodies (ANA), 22.5%, confirming results from previous studies. ANA occurrence did not correlate with gender, age, duration of MS, MS course, or disability in either the prospective and retrospective samples of MS patients. In 16 patients with MS tested at two time points, ANA occurrence did correlate with MS disease activity.
This suggests that the high frequency of ANA in MS reflects ongoing immune dysregulation.
Neurology. 1998 Aug;51(2):650.
PMID:9305354[PubMed - indexed for MEDLINE]
Mult Scler. 1999 Apr;5(2):121-5.
Autoimmunity in multiple sclerosis: study of a wide spectrum of autoantibodies.
Spadaro M, Amendolea MA, Mazzucconi MG, Fantozzi R, Di Lello R, Zangari P, Masala G.
SourceInstitute of Nervous and Mental Diseases, University of Rome La Sapienza, Italy.
The aim of this study was to assess the frequency of organ- and nonorgan-specific autoantibodies in MS patients and evaluate whether the presence of autoantibodies is an indicator of disease activity and/or a prognosis factor. One hundred and five definite MS patients in different stages and with different course and 75 blood donors were tested for the autoantibodies TgA, TMA/TPO-A, PCA, ANA, aCl, SMA, AMA and ANCA. All patients were screened for the LAC. Autoantibodies to at least one autoantigen were found in 66.6% MS patients and in 13.3% controls (P < 0.001). The frequency of TgA, TMA/TPO-A, ANA, aCl and SMA was statistically higher in patients than in controls. Circulating ANCAs were found in seven MS, a never reported finding. An early onset of MS (< 20 years) was associated with a lower autoantibody frequency (P < 0.01) Primary and secondary progressive MS had a higher antibody frequency than relapsing-remitting (P < 0.05) or benign (P < 0.001) MS.
Up to 86% of patients were autoantibody-positive during the acute stage, but only 30% of them remained positive during the remission stage (P < 0.001).
A generalised immune dysregulation occurs in MS patients, mostly during the acute stages and in the progressive courses, involving activation of both autoreactive Th1-cells (mainly linked to CNS lesions) and B-cells via Th2 cells.
PMID:10335521[PubMed - indexed for MEDLINE]
*****My MRI of brain and spine was clear (no lesions).
*****My symptoms are: polyneuropathy (mostly tingling but sometimes burning/itching/pricking/wet sensations, worst in feet and legs, but occurs in my hands, a spot on my back, my pelvic area, over my scalp, tongue, lips, and one side of my face - the left - as well sometimes), suspected autonomic neuropathy....
*****circulation problems (extremities are always ice cold in cooler weather, blueish/grey and splotchy, with numbness and tingling),
I would love to hear feedback on whether any of this is in line with your own symptoms. Do you have a positive ANA? Low vitamin D?
All the best,
The symptoms include several cyclic color changes:
1. When exposed to cold temperatures, the blood supply to the fingers or toes, and in some cases the nose or earlobes, is markedly reduced; the skin turns pale or white (called pallor), and becomes cold and numb.
2. When the oxygen supply is depleted, the skin colour turns blue (called cyanosis).
3. These events are episodic, and when the episode subsides or the area is warmed, the blood flow returns and the skin colour first turns red (rubor), and then back to normal, often accompanied by swelling, tingling, and a painful "pins and needles" sensation.
All three colour changes are observed in classic Raynaud's. However, not all patients see all of the aforementioned colour changes in all episodes, especially in milder cases of the condition. Symptoms are thought to be due to reactive hyperemias of the areas deprived of blood flow.
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