Best Description Yet

If it's on your mind and it has to do with multiple sclerosis in any way, post it here.

Best Description Yet

Postby OddDuck » Sun Jan 08, 2006 11:19 am

Well, now here is a good description of MS.

I'd say it does a pretty good job of meeting halfway the opposing viewpoints about whether MS is autoimmune or not. :wink: Or is it just double-talk?

hmmmmmmmmm................. I'm not sure if it says anything that we didn't know or not?


Clin Neurol Neurosurg. 2005 Dec 30; [Epub ahead of print] Links

Neuroinflammation in multiple sclerosis: Evidence for autoimmune dysregulation, not simple autoimmune reaction.

Grigoriadis N, Grigoriadis S, Polyzoidou E, Milonas I, Karussis D.

Department of Neurology, Laboratory of Experimental Neurology and Neuroimmunology, AHEPA University Hospital, Aristotle University of Thessaloniki, 1 Stilp Kyriakidi str 54636, Thessaloniki, Greece.

Both inflammatory and neurodegenerative components may contribute to the clinical profile of multiple sclerosis (MS) leading to irreversible deficits when they exceed the threshold of compensation. The mechanisms leading to tissue injury in MS are complex. Inflammation appears to be caused by overactive pro-inflammatory T-helper 1 cells, initiating an inflammatory cascade with several cellular and molecular immune components participating in the pathogenetic mechanism. Current treatments are most effective in the inflammatory phase of the disease since they may interfere with various stages of the immune cascade. Recent evidence has emerged that inflammation may not only be destructive, but may also play a part in tissue repair. This has opened up a new aspect of our knowledge of the role of the inflammatory process in MS. Data regarding the role of regulatory cells in particular, imply that specific immunomodulatory strategies that support the function of these particular cellular subpopulations may participate in the downregulation of autoimmune responses in MS.

PMID: 16388896 [PubMed - as supplied by publisher]
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