Glucocorticoid Metabolism and the Metabolic SyndromeThe metabolic syndrome is characterized by a group of metabolic risk factors in one person. They include:
· Abdominal obesity (excessive fat tissue in and around the abdomen)
· Atherogenic dyslipidemia (blood fat disorders — high triglycerides, low HDL cholesterol and high LDL cholesterol — that foster plaque buildups in artery walls)
· Elevated blood pressure
· Insulin resistance or glucose intolerance (the body can’t properly use insulin or blood sugar)
· Prothrombotic state (e.g., high fibrinogen or plasminogen activator inhibitor–1 in the blood)
· Proinflammatory state (e.g., elevated C-reactive protein in the blood)
The phenotype of the Metabolic Syndrome (hypertension, insulin resistance and hyperlipidaemia) bears similarities to Cushing's Syndrome, in which the cause of these features is elevated cortisol production....
CONCLUSIONS: These data support the concept that cortisol production is enhanced in the Metabolic Syndrome.
Leptin has been shown to be linked to adiposity and insulin resistance in middle-aged participants.
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