In the FYI FWIW category, here's a link to a free full text article: Incidental demyelinating inflammatory lesions in asymptomatic patients: a Brazilian cohort with radiologically isolated syndrome and a critical review of the literature
Quoting from the intro to the article:
The term radiologically isolated syndrome (RIS) was recently introduced to describe patients who have incidental brain magnetic resonance imaging (MRI) abnormalities suggestive of multiple sclerosis (MS), but without any signs or symptoms attributable to the disease1.
The current literature has demonstrated that RIS patients may
develop clinical symptoms, converting to either relapsing-remitting or primary progressive MS3.
Alternatively, patients may show progression in the MRI lesions without any objective clinical symptoms (radiologic progression);
patients may even show stabilized brain abnormalities in subsequent imaging examinations1-6
Take care all