Arthritis drugs hold promise for multiple sclerosis

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Arthritis drugs hold promise for multiple sclerosis

Postby MSUK » Tue Mar 13, 2012 1:37 am


A new class of drugs completing clinical trials soon for rheumatoid arthritis should be examined as a treatment for multiple sclerosis, according to the authors of a University of Alabama at Birmingham study published today in the Proceedings of the National Academy of Sciences.

The UAB study focused on a protein called “suppressor of cytokine signaling 3,” found in low levels among MS patients in relapse. With less SOCS3 to restrain it, rising levels of the protein STAT3 cause immune cells to release chemicals that strip the myelin coating from the brain’s nerve cells, which makes them less able to pass messages and causes symptoms from numbness to paralysis.

In a mouse model genetically engineered with low SOCS3 and high STAT3, a condition called experimental autoimmune encephalomyelitis (EAE), the mouse equivalent of MS, quickly developed. However, the research team reported that restored SOC3-signaling lowered STAT3 levels and reversed the disease.... Read More - ... ageid/3396
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Re: Arthritis drugs hold promise for multiple sclerosis

Postby Leonard » Wed Mar 14, 2012 2:33 am

of course, if it tackles the same cause, i.e. the misguided immune system by gut bacteria, arthritis drugs may work for MS too..
but there may be other ways to get the gut back in order..
see the last page 20 of general-discussion-f1/topic15188-285.html
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