MRF: Trial Examines Myelin Tolerization of the Immune System

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MRF: Trial Examines Myelin Tolerization of the Immune System

Postby rainer » Wed Mar 14, 2012 11:22 pm

I worry that myelin is not as important as they think, but nonetheless, fingers crossed. ... une-system

The Myelin Repair Foundation (MRF) announced that its research might soon lead into a clinical proof-of-concept trial at the Department of Neuroimmunology and Multiple Sclerosis Research, University Hospital Zürich, Switzerland, and the Institute for Neuroimmunology and Clinical Multiple Sclerosis Research in Hamburg, Germany. This clinical trial will determine the safety and efficacy of a potential therapeutic pathway to desensitize the immune system to myelin in multiple sclerosis (MS) patients, based on research conducted by MRF Investigator Stephen D. Miller from Northwestern University Feinberg School of Medicine.

"The Myelin Repair Foundation has established a solid scientific foundation to initiate this clinical trial that examines a potential targeted treatment pathway for MS patients, the first of its kind"” said Dr. Roland Martin, head of the Dept. of Neuroimmunology and MS Research in Zürich and former director of inims. "I am excited to lead MRF research into this clinical trial, which will examine the potential of a treatment specifically targeted to re-establish tolerance of myelin during the earliest stages of MS."

"I am thrilled that the scientific discoveries from my lab could impact MS patients all over the world," said MRF Investigator Stephen D. Miller, professor in microbiology-immunology at Northwestern’s Feinberg School. "The Myelin Repair Foundation’s support and unique research approach which facilitates collaboration with other leading neuroscientists supported by the MRF has sped up the research process to where we are today, moving an MS therapeutic closer to the patient with this clinical trial."

By inducing immune tolerance to myelin, a hospitable environment for myelin repair in MS patients is facilitated through two primary mechanisms: halting immune-mediated damage thus protecting myelin and minimizing the risk of infection, a frequent side effect of current MS therapeutics. This clinical trial will examine an antigen-specific MS therapy, a superior alternative to the non-discriminating immunosuppressive treatment regimen used currently for MS.
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