This is my best assessment of what is MS. It is the sketch of a new concept.
The condition to develop MS is prepared by venous insufficiency of the neck veins draining the brains. This breaks the BBB (in certain areas) and slows all sort of processes important in the vessel walls: feeding, transcription.
If you then get a bacteria outbreak like the Cpn (of which it is known that it may be sleeping in your body for years) or a virus (like EBV, also latent), even a vaccination for Hepatitis is suspect, these [or their ligands] will attach to cellular receptors. As these receptors dysfunction, their important role for feeding (cells, charging ion pump) or transcription (activate oligodendrocytes that then should compete to maintain the myeline and axons) gets further impaired. And if severe enough, you get MS (RR).
Some people may 'survive' this first stage of attack, stay reasonably ok and not be diagnosed with MS (but may have noted some symptoms on the way). But they are not there yet. Because at mid age, the gut comes up. Bacteria in the gut (you have many many more bacteria in your gut than cells in your body) manipulate T/B cells (and the immune system). Some people get diabetes or a rheumatic disorder from this. But our problem is a compromised BBB. And these bad T/B cells are misguided and get on the already weakened myeline. And they still get MS. Others who already got MS (RR) in the first stage have a fair chance to migrate to this second progressive phase.
If you then look at the graph of the age of onset, you see the double peak arise that is explained by the different underlying mechanisms.
Of course there are many other aspects on the fringe, to mention some: the mind-body connection (prolactin), the neuro pathways that get excited as part of the regulatory system of the metabolism, the role of zinc to bind and store insulin thereby enhancing insulin sensititity, the role of the liver as gatekeeper (Caucasian women), how things are interlinked with diabetes and diabetes related neuropathy, the attempts at tissue repair (Weiss U. Nature 2008), etc, etc, etc. People may be affected in different ways depending on genetic susceptibilities, environmental factors, the specific pattern of vascular insufficiencies of draining neck veins and so forth.
The challenge is now to subsume all the knowledge and expertise that is around already in a new more advanced model of what is MS and rapidly progress this matter for our cause..
Last edited by Leonard
on Thu Mar 22, 2012 2:15 am, edited 4 times in total.