HarryZ wrote:Would the sodium build up in the brain be caused by improper circulation...like that involved with CCSVI?
That doesn't make any sense at all. Why would sodium be more likely to build up than any other element dissolved in the blood?HarryZ wrote:Would the sodium build up in the brain be caused by improper circulation...like that involved with CCSVI?
Sodium ions are released in edema, Mark---it's a scientific fact. Found in venous congestion in the legs, liver, kidneys. Why not in the brain?
It's part of the renin-angiotensis system.
From a renal standpoint, an increase in venous congestion and pressure has both hemodynamic and intrinsic detrimental consequences on the kidneys as it reduces organ perfusion and increases Na retention.16 Of note, both pro-oxidant free radicals and pro-inflammatory cytokines such as tissue necrosis factor-a, which are released by the stretch endothelium in response to venous congestion, have been shown to reduce renal sodium excretion.22,23
Evidence is presented that an increase in renal venous pressure can cause sodium retention by a direct action on the kidney: a rise in venous pressure could thereby initiate a vicious circle by causing sodium retention, expansion of plasma volume, and further increase in venous pressure. This sequence of events may be crucial in the pathophysiology of cor pulmonale, and an exacerbating factor in other oedematous states.
The kidneys measure out chemicals like sodium, phosphorus, and potassium and release them back to the blood to return to the body. In this way, the kidneys regulate the body's level of these substances
cervocuit wrote:So now MS is a venous disease of the kidneys ?
http://kidney.niddk.nih.gov/kudiseases/ ... urkidneys/
I bet this is just a marker of neurodegeneration.
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