Is any remyelinating drug in Phase 1 trail ?
Is any remyelinating drug in Phase 1 trail ?
Is any remyelinating drug in Phase 1 trail or more ?
Gopi,
Re-myelination is being looked at all over the world.
Professor Neil Scolding in the UK is looking at stems cells to re-myelinate. The last I saw he was looking at human trials in 2-3 years.
http://www.mssociety.org.uk/search_clic ... eid=254673
The UK MS Society is also funding a myelin repair project based in Cambridge, UK. They are looking at 5-10 years.
http://www.mssociety.org.uk/research/re ... index.html
The Myelin Repair Foundation is focussed on Myelin repair - by the end of the decade.
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Canada is also funding a myelin repair project.
Several of the drugs companies are looking at ways to promote re-myelination e.g. Acorda Therapeutics. Most are in very early stages of development.
So lots going on but difficult to say when therapies to re-myelinate will be available - perhaps within 5 years (a guess).
But the other side of the coin is to stop the de-myelination and there are obviously lots of drugs in the pipeline which seek to do this.
But it is not just re-myelination. Loss of nerve fibres e.g. axons which are covered by myelin is considered to be the cause of disability. Lots of work is on-going to look at ways to regenerate lost nerve fibes e.g. nerve growth factors.
So lots going on at halting the disease and repairing the damage. Hope this helps.
Ian
Re-myelination is being looked at all over the world.
Professor Neil Scolding in the UK is looking at stems cells to re-myelinate. The last I saw he was looking at human trials in 2-3 years.
http://www.mssociety.org.uk/search_clic ... eid=254673
The UK MS Society is also funding a myelin repair project based in Cambridge, UK. They are looking at 5-10 years.
http://www.mssociety.org.uk/research/re ... index.html
The Myelin Repair Foundation is focussed on Myelin repair - by the end of the decade.
<shortened url>
Canada is also funding a myelin repair project.
Several of the drugs companies are looking at ways to promote re-myelination e.g. Acorda Therapeutics. Most are in very early stages of development.
So lots going on but difficult to say when therapies to re-myelinate will be available - perhaps within 5 years (a guess).
But the other side of the coin is to stop the de-myelination and there are obviously lots of drugs in the pipeline which seek to do this.
But it is not just re-myelination. Loss of nerve fibres e.g. axons which are covered by myelin is considered to be the cause of disability. Lots of work is on-going to look at ways to regenerate lost nerve fibes e.g. nerve growth factors.
So lots going on at halting the disease and repairing the damage. Hope this helps.
Ian