hi yea i read that there does seem to be low b12 and elevated homocysteine in your typical ms patient.
i have had chronically low b12 due to dietary negligence but typically i think in ms sufferers there is a b12 absorption problem which drives up the homocysteine coz ur bod is not processing it properly. i don't match because my homocysteine is lower than your average non-ms study participant. confusing.
neway i think the low b12 is common to ms patients whether ur in the subset w c. pneumoniae infection or not. so apparently, you want to avoid cyanocobalamin and take methylcobalamin - my doc has me on 1000mcg q 3 weekly, and my serum b12 is up to 640 while my homocysteine is 6. b12 is neuroprotective so it's good stuff for us ms-ers. also i believe you need calcium to properly absorb b12.
here's an abstract linking calcium and cobalamin absorption (in this case the gut's prob with absorbing b12 was caused by a medication):
Diabetes Care. 2000 Sep;23(9):1227-31. Related Articles, Links
Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin.
Bauman WA, Shaw S, Jayatilleke E, Spungen AM, Herbert V.
Department of Medicine, Mount Sinai School of Medicine, New York, USA. firstname.lastname@example.org
OBJECTIVE: Of patients who are prescribed metformin, 10-30% have evidence of reduced vitamin B12 absorption. B12-intrinsic factor complex uptake by ileal cell surface receptors is known to be a process dependent on calcium availability Metformin affects calcium-dependent membrane action. The objective of this study was to determine the magnitude and mechanism of the reduction in serum vitamin B12 after metformin administration. RESEARCH DESIGN AND METHODS: A comparative study design was employed using 2 groups (metformin and control). A total of 21 patients with type 2 diabetes received sulfonylurea therapy; 14 of these 21 patients were switched to metformin. Monthly serum total vitamin B12 measurements and holotranscobalamin (holoTCII) (B12-TCII) were performed. After 3 months of metformin therapy, oral calcium supplementation was administered. RESULTS: Serial serum vitamin B12 determinations revealed a similar decline in vitamin B12 and holoTCII. Oral calcium supplementation reversed the metformin-induced serum holoTCII depression. CONCLUSIONS: Patients receiving metformin have diminished B12 absorption and low serum total vitamin B12 and TCII-B12 levels because of a calcium-dependent ileal membrane antagonism, an effect reversed with supplemental calcium.