Patients with MS have low levels of Egr2/3 protein in Tcells

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Patients with MS have low levels of Egr2/3 protein in Tcells

Postby MSUK » Thu Dec 13, 2012 3:10 am


Researchers from Queen Mary, University of London have discovered that two proteins which are believed to play a key role in controlling the body's immune response are found in lower levels in T lymphocytes from patients with multiple sclerosis (MS).

The study found that MS patients' T lymphocytes - types of white blood cells which play an important role in the immune system - were defective at producing the proteins and that this was associated with increased levels of molecules which promote inflammation. The findings are reported in the Journal of Immunology-. The work follows on from a recent study published in the journal Immunity- in which the lead scientists first identified the two proteins - known as Egr2 and Egr3 - as being important in both protecting against the development of inflammatory autoimmune diseases, like MS and arthritis, and also in preventing chronic virus infections such as HIV and hepatitis... Read More - ... ageid/3515
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