Yes I had/have this symptom.
I tried all the bladder drugs but they did not work - especially at night.
I was advised to have Botox and was waiting for my appointment when I was put on Cymbalta (duloxetine). Bizzarrely, what is a 'negative' side-effect for most turNed out to be a fantastic benefit for my bladder. I now only go once during the night - compared with 20+ times before.
Perhaps try it if you have tried everything else. I found the first two weeks on it absolutely horrible - racing heart, edgy, insomnia - but it kicked in about 15-20 days after starting it. I hope this helps you and PM me if you need more info.
RR-MS dx 1998 and Coeliac dx 2003
Copaxone, Cymbalta. EPO, Fish Oils, Vitamin D3 2000 IU daily, Cal/Mag/Zinc, Multivitamin/mineral, Co-Enzyme Q10, Probiotics, Milk Thistle.