Another reason to take GABA...cortisol suppression

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Another reason to take GABA...cortisol suppression

Postby Anonymoose » Tue Jan 15, 2013 12:34 pm

GABA inhibits release of ACTH which triggers cortisol production. (cleaning up browser...sorry for being a board hog) ... tNr=236410
Effect of Gamma-Aminobutyric Acid (GABA) and GABA Antagonist Drugs on ACTH Release
Makara GB, Stark E
Neuroendocrinology 1974;16:178–190 (DOI: 10.1159/000122564)

Corticotrophin (ACTH) release has been studied in rats given intraventricular gamma-aminobutyric acid (GABA) infusions or injections of picrotoxin and bicuculline. As an index of ACTH release the corticosterone level of blood or plasma was determined. GABA (1 M/liter), infused at a rate of 1 µl/min into the 3rd ventricle, inhibited the rise in plasma corticosterone normally produced by surgical trauma. 60 min after surgical trauma the rats given GABA infusions had lower blood corticosterone levels than the control rats given infusions of 1 M/liter of proline, 1 M/liter of glycine, or 0.15 M/liter of sodium chloride. Picrotoxin, an antagonist of GABA, is a potent stimulus of ACTH release. In sub-convulsive intraperitoneal doses it produced a significant rise in plasma corticosterone in conscious rats with complete hypothalamic deafferentation. Under pentobarbital anesthesia 12.5 µg of picrotoxin injected into the 3rd ventricle produced a small but significant rise in plasma corticosterone in rats with hypothalamic deafferentation. After intraventricular injections of bicuculline methiodide a significant rise in plasma corticosterone occurred in rats with hypothalamic deafferentation; the ACTH releasing effect of 2.5 µg of bicuculline methiodide was strongly inhibited by a simultaneous infusion of 0.15 M/liter of GABA. On the basis of this pharmacological evidence, we suggest that GABA may be an inhibitory neurotransmitter of hypothalamic interneurons and/or afferent pathways involved in the regulation of ACTH release.
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Re: Another reason to take GABA...cortisol suppression

Postby jimmylegs » Tue Jan 15, 2013 1:04 pm

from 2010

GABA status is correlated with your zinc status. and that's only one of hundreds of important body functions in which zinc is involved.

zinc and GABA and the brain:
Release of glutamate and GABA in the hippocampus under zinc deficiency (2003) ... 0/abstract
Zinc homeostasis in the brain is affected by dietary zinc deficiency, and its alteration may cause brain dysfunctions... Gamma aminobutyric acid (GABA) concentration in the hippocampal extracellular fluid during stimulation with high K+ was increased in the control rats, but not in the zinc-deficient rats.

Impairment of GABAergic neurotransmitter system in the amygdala of young rats after 4-week zinc deprivation (2006) ... 8606002233
the basal GABA concentration in the amygdalar extracellular fluid was significantly lower in zinc-deficient rats and was not increased both in the control and zinc-deficient rats by stimulation with 100 mM KCl. These results suggest that GABAergic neurotransmitter system is critically impaired in the amygdala of young rats after 4-week zinc deprivation.

and as i've posted elsewhere, the WHO thinks about 30% of the population are zinc deficient, whether we live in developed or developing countries.


without adequate zinc, your liver cannot convert amino acid breakdown products to uric acid. all that happens is the ammonia byproduct from which uric acid is made (using zinc) goes up - people with low uric acid can have high levels of ammonia in their system.

...An individual is unlikely to become hyperammonemic unless the conversion system is impaired in some way. In newborns, this impairment is often the result of genetic defects, whereas, in older individuals, the impairment is more often the consequence of a diseased liver.
As ammonia exceeds normal concentration, an increased disturbance of neurotransmission and synthesis of both GABA and glutamine occurs in the CNS. A correlation between arterial ammonia concentration and brain glutamine content in humans has been described. Moreover, brain content of glutamine is correlated with intracranial pressure. In vitro data also suggest that direct glutamine application to astrocytes in culture causes free radical production and induces the membrane permeability transition phenomenon, which leads to ionic gradient dissipation and consequent mitochondrial dysfunction...
obviously i don't think we're on the verge of coma but there must be a continuum of issues all the way up to fatal cases of hyperammonemia.
odd sx? no dx? check w/ dietitian
99% don't meet these. meds/lifestyle can affect levels
status can be low in ms & other cond'ns
'but my results are normal'. typical panels don't test all
deficits occur in 'normal' range
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Re: Another reason to take GABA...cortisol suppression

Postby Anonymoose » Tue Jan 15, 2013 1:09 pm

Hehe...I saw so many posts about GABA. I couldn't link to them all and I didn't want to choose just a few. I knew you'd jump in with your zinc though. Good stuff that zinc. :)
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Re: Another reason to take GABA...cortisol suppression

Postby Cece » Wed Jan 16, 2013 6:20 pm

Interesting!! I would think cortisol suppression would be a good thing.
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