Fibroblast Growth Factor-23 /vitamin D levels and RAAS

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Fibroblast Growth Factor-23 /vitamin D levels and RAAS

Postby Anonymoose » Sat Jan 26, 2013 1:10 pm

RAAS=>aldosterone
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171931/
Cross talk between the renin-angiotensin-aldosterone system and vitamin D-FGF-23-klotho in chronic kidney disease.
de Borst MH, Vervloet MG, ter Wee PM, Navis G.
Source
Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen and University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. m.h.de.borst@int.umcg.nl
Abstract
There is increasingly evidence that the interactions between vitamin D, fibroblast growth factor 23 (FGF-23), and klotho form an endocrine axis for calcium and phosphate metabolism, and derangement of this axis contributes to the progression of renal disease. Several recent studies also demonstrate negative regulation of the renin gene by vitamin D. In chronic kidney disease (CKD), low levels of calcitriol, due to the loss of 1-alpha hydroxylase, increase renal renin production. Activation of the renin-angiotensin-aldosterone system (RAAS), in turn, reduces renal expression of klotho, a crucial factor for proper FGF-23 signaling. The resulting high FGF-23 levels suppress 1-alpha hydroxylase, further lowering calcitriol. This feedback loop results in vitamin D deficiency, RAAS activation, high FGF-23 levels, and renal klotho deficiency, all of which associate with progression of renal damage. Here we examine current evidence for an interaction between the RAAS and the vitamin D-FGF-23-klotho axis as well as its possible implications for progression of CKD.

http://onlinelibrary.wiley.com/doi/10.1 ... 01264/full
FGF-23 Is a Potent Regulator of Vitamin D Metabolism and Phosphate Homeostasis†


I wonder what else can be attributed to high FGF23.
Anonymoose
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Re: Fibroblast Growth Factor-23 /vitamin D levels and RAAS

Postby Anonymoose » Sat Jan 26, 2013 1:24 pm

Just to complete the connection with ms...
http://www.ncbi.nlm.nih.gov/m/pubmed/19706421/
We now show that the RAAS also plays a major role in autoimmunity, exemplified by multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Using proteomics, we observed that RAAS is up-regulated in brain lesions of MS. AT1R was induced in myelin-specific CD4+ T cells and monocytes during autoimmune neuroinflammation.
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