One of the less known testosterone actions is neuroprotection. There are some evidences supporting the hypothesis that testosterone may act protectively in neurodegenerative disorders, e.g. Alzheimer's disease (AD), mild cognitive impairment (MCI) or depression. Androgens alter also the morphology, survival and axonal regeneration of motor neurons.........Testosterone... does not provide significant neuroprotection against glutamate-induced neurotoxicity.
Thus, depending on the predominance of one receptor mechanism over another, the outcome of androgen treatment may be very different and, as such, could help explain existing discrepancies as to whether androgens are protective or damage inducing.
are definitely intriguing and I've never thought about it that way.Could it be that MSers bodies reduce Testosterone production to try to protect vulnerable nerve cells from it's harmful effects? In which case I may be doing myself harm by supplementing?
"Hormones may show concentration effects, with opposite actions at low and high levels. Although estrogens facilitate immune responses at low concentration, they suppress immune responses at high concentrations. Sex hormones are involved in feedback loops that inhibit their own production. Links between the endocrine and immune systems are reinforced by the multiple and diverse effects of sex hormones on the immune system. In turn, glucocorticoids suppress sex hormone production and actions."
I think the message there might be, for men and women, don't automatically assume that lesions may be interfering with sexual functioning, in some cases that might be the case, but in others it might be low testosterone levels contributing to the dysfunction. If that's the case, it may be possible to correct it with testosterone."...four men who had MS and sexual dysfunction were found to have abnormally low testosterone levels, believed to be on a hypothalamic basis. The dysfunction improved with testosterone therapy."
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