this stuff is not confusing to me.. complex, sure, but not incomprehensible.. but then i have been reading about it for quite a few yrs now.yes you can have too much of an essential nutrient, or too little. yes, zinc toxicity is bad for you:
Multiple sclerosis and the workplacehttp://www.neurology.org/content/37/10/1672.short
(industry cluster. serum levels? exposure? was this 'ms', or zinc toxicity/copper deficiency neuropathy?)
Denture cream.An unusual source of excess zinc, leading to hypocupremia and neurologic diseasehttps://www.neurology.org/content/71/9/639.abstract
(serum levels 20-65 umol/L)
Letter: re DENTURE CREAM: AN UNUSUAL SOURCE OF EXCESS ZINC, LEADING TO HYPOCUPREMIA AND NEUROLOGIC DISEASEhttps://www.neurology.org/content/73/1/76.1.extract
(at doses around 150mg per day!)yes, zinc toxicity can be fatal, never mind little old ms:
Fatal copper deficiency from excessive use of zinc-based denture adhesivehttp://www.ncbi.nlm.nih.gov/pubmed/20555248
(i can't get this one - anyone have the serum values for copper and zinc here?)
Acute intravenous zinc poisoning (this is a terribly sad case report starting with crohn's/bowel resection/zinc deficiency followed by zinc treatment error)http://www.ncbi.nlm.nih.gov/pmc/article ... 4-0024.pdf
"... zinc intoxication was confirmed by analysing the intravenous solutions prescribed and by a serum zinc concentration of 640 umol/l"yes, zinc as an essential nutrient is low in ms
Zinc and copper in multiple sclerosis.http://jnnp.bmj.com/content/45/8/691.short
Iron and zinc status in multiple sclerosis patients with pressure soreshttp://europepmc.org/abstract/MED/33965 ... VJX477s.24
The Co-Occurrence of Multiple Sclerosis and Migraine Headache: The Serotoninergic Linkhttp://informahealthcare.com/doi/abs/10 ... 9408986007
Serum level of iron, zinc and copper in patients with multiple sclerosishttp://jmj.jums.ac.ir/~jumsjmj/files/si ... 0187b3.pdf
Serum chemical elements and oxidative status in Alzheimer's disease, Parkinson disease and multiple sclerosis.http://www.ncbi.nlm.nih.gov/pubmed/17267042
"To obtain a profile of chemical elements and oxidative status in complex neurological diseases, an unbiased "omics" approach, i.e., quantification of 26 elements and oxidative stress parameters (serum oxidative status (SOS) and serum anti-oxidant capacity (SAC)), combined with multivariate statistical procedures (forward discriminant analysis, FDA) to analyse the vast amount of data, was applied to four groups of subjects (53 patients with Alzheimer's disease (AD), 71 with Parkinson disease (PD), 60 with multiple sclerosis (MS) and 124 healthy individuals). Descriptive statistics revealed numerous differences between each disease and healthy status. A concordant imbalance (reduction in Fe, Zn and SAC, and increase in SOS) was shared by AD, PD and MS
." yes, zinc dysregulation has been reported in ms patients compared to controls:
Zinc in multiple sclerosis. II: Correlation with disease activity and elevated plasma membrane–bound zinc in erythrocytes from patients with multiple sclerosis
"Previous studies have shown that zinc levels in erythrocytes are significantly elevated in patients with multiple sclerosis (MS). ... erythrocyte Zn levels ... were dramatically decreased during a clinically documented exacerbation of MS. ... mechanisms which govern cellular availability, compartmentalization of Zn, or the binding of Zn to cell surface membranes may be altered in patients with MS, and that these mechanisms vary with disease activity"
Zinc in muliple [sic] sclerosishttp://onlinelibrary.wiley.com/doi/10.1 ... 9/abstract
"Erythrocyte-bound zinc levels were significantly increased (p < 0.05) in patients with multiple sclerosis when compared with control subjects. ... these values may suggest alterations in the control mechanisms governing zinc compartmentalization in patients with multiple sclerosis."
Essential fatty acid and lipid profiles in plasma and erythrocytes in patients with multiple sclerosishttp://ajcn.nutrition.org/content/50/4/801.short
"...altered levels of cholesterol in plasma and erythrocytes from MS patients may contribute to increased erythrocyte-membrane Zn in MS patients"and though more research is needed, ms patients have been shown to consume less than RDA for zinc
(which is a mere 8-11mg for adults; upper limit 40mg)http://msj.sagepub.com/content/11/1/24.short
in comparison, about half of the general public aren't getting enough daily zinc - adult mean intake was 13mg as per NHANES 3 http://www.idpas.org/pdf/2791ZincIntakeOfUS.pdf
" Mean total zinc intakes were 0.7 mg higher in adolescents (11.1 mg) and 2.5–3.5 mg higher in adults (13 mg) compared with mean dietary intakes"
“Adequate” zinc intake in this survey population was 55.6% based on total intakes of >77% of the 1989 recommended dietary allowance."
and no, you don't want low or high copper either. you want the copper zinc ratio around 1.1.
healthy controls repeatedly average serum zinc about 18, and that means serum copper around 17.
i have yet to see any TiMS member's serum zinc result come back high (with the exception of mine, once, when i was just learning, and working on my very first deficiency correction). and i have yet to see any TiMS member test for serum zinc and copper and have it optimal on the first try.